Lack of Relationship Between Sympathetic Nervous System Activity, Measured by Two Circulating Markers, and Blood Pressure in Diabetic and Nondiabetic Subjects
| Autor: | M.W. Savage, M.J. Sampson, Gareth Williams, J.S. Yudkin, E. Carstensen, MA Ware |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Sympathetic nervous system medicine.medical_specialty Sympathetic Nervous System Ambulatory blood pressure Systole Endocrinology Diabetes and Metabolism medicine.medical_treatment Normal Distribution Blood Pressure Norepinephrine (medication) Norepinephrine Endocrinology Diastole Reference Values Diabetes mellitus Internal medicine Blood plasma Diabetes Mellitus Internal Medicine medicine Humans Neuropeptide Y Obesity Aged business.industry Insulin Middle Aged medicine.disease humanities Blood pressure medicine.anatomical_structure Diabetes Mellitus Type 2 Catecholamine Female business Biomarkers medicine.drug |
| Zdroj: | Journal of Diabetes and its Complications. 12:140-146 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/s1056-8727(97)00079-2 |
| Popis: | Two putative sympathetic nervous system (SNS) markers, noradrenaline and neuropeptide Y (NPY) were related to 24-h ambulatory blood pressure (BP) in 59 normotensive subjects, 34 non-insulin-dependent diabetics, and 25 controls. Plasma NPY levels were not significantly different between the two groups [non-insulin-dependent (NIDDM) diabetes mellitus 4.33 (3.25-5.78), controls 5.68 (3.39-6.97) p=0.26] as were those of noradrenaline (1.51+/-0.69 versus 1.78+/-0.55; p=0.053). There were correlations, controlled for age and obesity, of plasma NPY with clinic and night time diastolic BP in the control group only (r=0.49 [p=0.013] and r=0.48 [p=0.023] respectively). No similar correlation was found in the NIDDM group, or between plasma noradrenaline and blood pressure in either group. No correlation was found between plasma insulin and NPY or noradrenaline levels. There is a weak independent relationship between NPY and blood pressure in normotensive nondiabetics but not in NIDDM subjects. We found no evidence for the hypothesis that insulin modulates blood pressure through activity of the SNS. |
| Databáze: | OpenAIRE |
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