MEDULLARY AND CORTICAL THICK ASCENDING LIMB: SIMILARITIES AND DIFFERENCES
| Autor: | Caroline Prot-Bertoye, Lise Bankir, Lucile Figueres, J. Howard Pratt, Gilles Crambert, Pascal Houillier, Nadine Bouby |
|---|---|
| Přispěvatelé: | Métabolisme et physiologie rénales (ERL 8228), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Métabolisme et physiologie rénale (CRC - UMR_S 1138), Indiana University School of Medicine, Indiana University System, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
hormonal regulation
Kidney Cortex Physiology medulla Tubular fluid 030204 cardiovascular system & hematology [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology Evolution Molecular 03 medical and health sciences 0302 clinical medicine Species Specificity genetic disease Cortex (anatomy) medicine Loop of Henle [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Animals Humans Distal convoluted tubule Na+-K+-2Cl− cotransporter Medulla 030304 developmental biology Kidney Medulla 0303 health sciences Chemistry urogenital system Membrane Transport Proteins Water-Electrolyte Balance Apical membrane Adaptation Physiological Renal Reabsorption Cell biology medicine.anatomical_structure cortex Cotransporter Homeostasis |
| Zdroj: | AJP Renal Physiology AJP Renal Physiology, American Physiological Society, 2020, 318 (2), pp.F422-F442. ⟨10.1152/ajprenal.00261.2019⟩ |
| ISSN: | 0363-6127 1522-1466 |
| Popis: | The thick ascending limb of the loop of Henle (TAL) is the first segment of the distal nephron, extending through the whole outer medulla and cortex, two regions with different composition of the peritubular environment. The TAL plays a critical role in the control of NaCl, water, acid, and divalent cation homeostasis, as illustrated by the consequences of the various monogenic diseases that affect the TAL. It delivers tubular fluid to the distal convoluted tubule and thereby affects the function of the downstream tubular segments. The TAL is commonly considered as a whole. However, many structural and functional differences exist between its medullary and cortical parts. The present review summarizes the available data regarding the similarities and differences between the medullary and cortical parts of the TAL. Both subsegments reabsorb NaCl and have high Na+-K+-ATPase activity and negligible water permeability; however, they express distinct isoforms of the Na+-K+-2Cl−cotransporter at the apical membrane. Ammonia and bicarbonate are mostly reabsorbed in the medullary TAL, whereas Ca2+and Mg2+are mostly reabsorbed in the cortical TAL. The peptidic hormone receptors controlling transport in the TAL are not homogeneously expressed along the cortical and medullary TAL. Besides this axial heterogeneity, structural and functional differences are also apparent between species, which underscores the link between properties and role of the TAL under various environments. |
| Databáze: | OpenAIRE |
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