The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis
| Autor: | Andrew L. Concoff, Jeffrey Rosen, Faizan Niazi, Peter Shaw, Parag Sancheti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Osteoarthritis (OA)
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Sports medicine Intra-articular hyaluronic acid (IA-HA) Osteoarthritis Injections Intra-Articular 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Pain Management Orthopedics and Sports Medicine Knee 030212 general & internal medicine Dosing Hyaluronic Acid Adverse effect Randomized Controlled Trials as Topic 030203 arthritis & rheumatology Viscosupplements business.industry Osteoarthritis Knee medicine.disease Knee pain Treatment Outcome Relative risk Meta-analysis medicine.symptom lcsh:RC925-935 business Research Article |
| Zdroj: | BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-14 (2017) BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| Popis: | Background Intra-articular hyaluronic acid (IA-HA) is a common therapy used to treat knee pain and suppress knee inflammation in knee osteoarthritis (OA), typically prescribed in regimens ranging from a single injection to 5 weekly injections given once weekly. We conducted a systematic review to determine the efficacy of IA-HA, with subgroup analyses to explore the differences in knee pain and adverse events (AEs) across different dosing regimens. Methods We conducted a systematic search of the literature to identify studies evaluating IA-HA for the management of knee OA compared to IA-saline. Primary outcome measure was the mean knee pain score at 13 Weeks (3 months) or 26 weeks (6 months). Secondary outcome was the number of treatment-related AEs and treatment-related serious adverse events (SAEs). We evaluated differences in levels of pain and AEs/SAEs between dosing regimens compared to IA-Saline. Results Thirty articles were included. Overall, IA-HA injections were associated with less knee pain compared to IA-Saline injections for all dosing regimens. 2–4 injections of IA-HA vs. IA-Saline produced the largest effect size at both 3-months and 6-months (Standard mean difference [SMD] = −0.76; −0.98 to −0.53, 95% CI, P |
| Databáze: | OpenAIRE |
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