Determination of pesticides and veterinary drug residues in food by liquid chromatography-mass spectrometry: A review
| Autor: | Agustín Llopis-González, Ana Masiá, María Morales Suárez-Varela, Yolanda Picó |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), European Commission, Universidad de Valencia, Picó, Yolanda, Picó, Yolanda [0000-0002-9545-0965] |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Veterinary Drugs
Resolution (mass spectrometry) Veterinary drugs Sample preparation Food Contamination 01 natural sciences Biochemistry Quantitative accuracy Mass Spectrometry Analytical Chemistry Liquid chromatography–mass spectrometry Environmental Chemistry Veterinary drug Pesticides Liquid chromatography-mass spectrometry Spectroscopy Chromatography 010405 organic chemistry Chemistry business.industry 010401 analytical chemistry Research needs Pesticide Food safety Drug Residues 0104 chemical sciences Food Biochemical engineering business Chromatography Liquid |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Monitoring of pesticides and veterinary drug residues is required to enforce legislation and guarantee food safety. Liquid chromatography-mass spectrometry (LC-MS) is the prevailing technique for assessing both types of residues because LC offers a versatile and universal separation mechanism suitable for non-gas chromatography (GC) amenable and the majority of GC-amenable compounds. This characteristic becomes more relevant when LC is coupled to MS because the high sensitivity and specificity of the detector allows to apply generic sample preparation procedures, which simultaneously extract a wide variety of residues with different physico-chemical properties. Determination of metabolites and degradation products, non-target suspected screening of an increasing number of residues, and even unknowns identification are also becoming inherent LC-MS advantages thanks to the latest advances. For routine analysis and, in particular, for official surveillance purposes in food control, analytical methods properly validated following strict guidelines are needed. After a brief introduction and an outline of the legislation applicable around the world, aspects such as improvement of specificity of high-throughput methods, resolution and mass accuracy of identification strategies and quantitative accuracy are critically reviewed in this article. In them, extraction, separation and determination are emphasized. The main objective is to offer an assessment of the state of the art and identify research needs and future trends in determining pesticide and veterinary drug residues in food by LC-MS This work has been co-supported by the Spanish Ministry of Economy and Competitiveness and the ERDF (European Regional Development Fund) through the project CGL2015-64454-C2-1-R as well as by the University of Valencia through the project UV-INV-AE15-348995 |
| Databáze: | OpenAIRE |
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