| Autor: |
Sean Vandersluis, Jennifer C. Reid, Luca Orlando, Mickie Bhatia |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Drug discovery today. 27(12) |
| ISSN: |
1878-5832 |
| Popis: |
The discovery and development of effective drugs for cancer patients has seen limited success in the clinic from phase I trials onward. The high attrition rate of current drug development approaches requires careful evaluation to provide a better understanding of the factors that correlate with or predict positive clinical outcomes. Here, we examine pre-clinical drug development approaches and conduct a meta-analysis of 2918 clinical studies involving 466 unique drugs tested in clinical trials for acute myeloid leukemia (AML). Our goal was to determine whether there are key shared pre-clinical characteristics that ultimately relate to successful or unsuccessful drugs in patients. We provide an evidence-based recommendation for the use of phenotypic drug discovery rather than other methods during pre-clinical development. Although our analysis was limited to AML, similar analyses are likely to be informative for other tumor-specific drug discovery campaigns, informing and improving the foundational discovery screens and platforms for other cancers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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