The Gut-Arterial Stiffness Axis: Is TMAO a Novel Target to Prevent Age-Related Aortic Stiffening?
| Autor: | Gary L. Pierce, Colin J Gimblet, Stephen J. Roy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Adolescent Blood Pressure Pulse Wave Analysis Article Mice Young Adult Methylamines Vascular Stiffness Age related Internal medicine Internal Medicine medicine Animals Humans Aorta Aged Chemistry Age Factors Middle Aged medicine.disease Stiffening Blood pressure Arterial stiffness Cardiology Female |
| Zdroj: | Hypertension |
| ISSN: | 1524-4563 |
| Popis: | Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using complementary translational approaches in mice and humans, we investigated the role of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) in age-related aortic stiffening and increased SBP. Aortic stiffness was measured using carotid-femoral (c-f) or aortic (a) pulse wave velocity (PWV) in humans and mice, respectively. Study 1: Plasma TMAO concentrations were elevated (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|