Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet–Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy
| Autor: | Ya-Fang Xiao, Wen-Cheng Chen, Jia-Xiong Chen, Guihong Lu, Shuang Tian, Xiao Cui, Zhen Zhang, Huan Chen, Yingpeng Wan, Shengliang Li, Chun-Sing Lee |
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| Rok vydání: | 2022 |
| Předmět: |
Drug Carriers
Mice Inbred BALB C Photosensitizing Agents Light Phosphatidylethanolamines Imidazoles Mice Nude Polyethylene Glycols Mice Photochemotherapy A549 Cells Neoplasms NIH 3T3 Cells Animals Humans Nanoparticles Tumor Hypoxia Female General Materials Science Reactive Oxygen Species Phenanthrolines |
| Zdroj: | ACS Applied Materials & Interfaces. 14:5112-5121 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Type-I photodynamic therapy (PDT) with less oxygen consumption shows great potential for overcoming the vicious hypoxia typically observed in solid tumors. However, the development of type-I PDT is hindered by insufficient radical generation and the ambiguous design strategy of type-I photosensitizers (PSs). Therefore, developing highly efficient type-I PSs and unveiling their structure-function relationship are still urgent and challenging. Herein, we develop two phenanthro[9,10 |
| Databáze: | OpenAIRE |
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