Sexual dysfunction in dialysis patients treated with antihypertensive or antidepressive medications: results from the DOPPS
| Autor: | Eric W. Young, David C. Mendelssohn, Donna Mapes, Nancy A. Mason, Stacey J. Elder, Shunichi Fukuhara, Antonio Alberto Lopes, Yasushi Asano, George R. Bailie, Juergen Bommer, Jose Miguel Cruz |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Antihypertensive agents Vasodilator Agents medicine.medical_treatment Sexual dysfunction Antidepressive Agents Tricyclic Global Health Medication prescription Benzodiazepines Renal Dialysis Germany Internal medicine medicine Humans Adrenergic alpha-Antagonists Antihypertensive Agents Dialysis Antidepressives Aged Transplantation business.industry Middle Aged medicine.disease Health Surveys Comorbidity Antidepressive Agents Surgery Haemodialysis Sexual Dysfunction Physiological Medication-related Logistic Models Spain Nephrology Sex life Quality of Life Kidney Failure Chronic Female France Hemodialysis medicine.symptom Sexual function business Kidney disease |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfl755 |
| Popis: | Texto completo: acesso restrito. p. 1163-1170 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-31T14:34:16Z No. of bitstreams: 1 10.1093ndt-gfl755.pdf: 130083 bytes, checksum: 014945e9814db5d9f30b3ea19c220423 (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T15:59:36Z (GMT) No. of bitstreams: 1 10.1093ndt-gfl755.pdf: 130083 bytes, checksum: 014945e9814db5d9f30b3ea19c220423 (MD5) Made available in DSpace on 2014-09-09T15:59:36Z (GMT). No. of bitstreams: 1 10.1093ndt-gfl755.pdf: 130083 bytes, checksum: 014945e9814db5d9f30b3ea19c220423 (MD5) Previous issue date: 2007 Background. The relationship between medication prescription and sexual dysfunction (SD) in dialysis patients is unclear. Methods. We studied antihypertensive and antidepressive agents prescribed for 7346 patients in the Dialysis Outcomes and Practice Patterns Study phase 1 (DOPPS I) and 8891 patients in DOPPS II. At baseline, DOPPS I patients completed a quality of life survey, including four questions about sexual functioning, from which we created a composite SD scale. DOPPS II patients were asked only one question about SD. We examined predictors of SD with logistic regression, using numerous patient characteristics, comorbid conditions and additional variables. Results. Reported SD ranged from 66.4% (France) to 84.5% (Spain). The mean composite SD score ranged from 6.4 (Spain) to 7.9 (Germany) (on a 3–15 scale). Peripheral α-blockers increased odds of DOPPS I patients having their sex life bothered by end-stage renal disease (ESRD) (OR = 1.18), and there were elevated odds of arousal problems with central antagonists, loop diuretics and peripheral α-blockers (OR = 1.19, 1.24 and 1.29, respectively). Selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines increased odds of problems with enjoyment (OR = 1.59 and 1.26, respectively) and arousal (OR = 1.70 and 1.24, respectively), and having sex life bothered by ESRD (DOPPS I: OR = 1.36 and 1.24; DOPPS II: 1.30 and 1.31, respectively). Vasodilators reduced the odds of sexual enjoyment problems (OR = 0.75). Composite SD scores worsened with peripheral α-blockers (+0.41), tricyclics (+0.78), SSRIs (+0.80) and benzodiazepines (+0.50), but not with vasodilators (−0.57). Conclusions. Awareness of associations between SD and prescribed medications may offer opportunities for intervention. |
| Databáze: | OpenAIRE |
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