Registry on acute cardiovascular events during endurance running races: the prospective RACE Paris registry
| Autor: | Benoît Gerardin, Catherine Fleischel, Hakim Benamer, Hazrije Mustafic, Anne Bellemain-Appaix, Lionel Lamhaut, Jean-Philippe Collet, Jacques Monsegu, Bernard Livarek, Emmanuel Teiger, Pierre Aubry, M. Jaffry |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Paris Pediatrics medicine.medical_specialty Acute coronary syndrome 030204 cardiovascular system & hematology Sudden death Running 03 medical and health sciences 0302 clinical medicine Risk Factors Case fatality rate Humans Medicine Prospective Studies Registries 030212 general & internal medicine Treadmill business.industry Incidence (epidemiology) Medical record Hypertrophic cardiomyopathy medicine.disease Surgery Death Sudden Cardiac Etiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal. 37:2531-2541 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehv675 |
| Popis: | Aim Long distance running races are associated with a low risk of life-threatening events much often attributed to hypertrophic cardiomyopathy. However, retrospective analyses of aetiology lack consistency. Methods and results Incidence and aetiology of life-threatening/fatal events were assessed in long distance races in the prospective Registre des Accidents Cardiaques lors des courses d'Endurance (RACE Paris Registry) from October 2006 to September 2012. Characteristics of life-threatening/fatal events were analysed by interviewing survivors and reviewing medical records including post-mortem data of each case. Seventeen life-threatening events were identified of 511 880 runners of which two were fatal. The vast majority were cardiovascular events (13/17) occurring in experienced male runners [mean (±SD) age 43 ± 10 years], with infrequent cardiovascular risk factors, atypical warning symptoms prior to the race or negative treadmill test when performed. Acute myocardial ischaemia was the predominant aetiology (8 of 13) and led to immediate myocardial revascularization. All cases with initial shockable rhythm survived. There was no difference in event rate according to marathons vs. half-marathons and events were clustered at the end of the race. A meta-analysis of all available studies including the RACE Paris registry ( n = 6) demonstrated a low prevalence of life-threatening events (0.75/100 000) and that presentation with non-shockable rhythm [OR = 29.9; 95% CI (4.0–222.5), P = 0.001] or non-ischaemic aetiology [OR = 6.4; 95% CI (1.4–28.8), P = 0.015] were associated with case-fatality. Conclusion Life-threatening/fatal events during long distance races are rare, most often unpredictable and mainly due to acute myocardial ischaemia. Presentation with non-shockable rhythm and non-ischaemic aetiology are the major determinant of case fatality. |
| Databáze: | OpenAIRE |
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