UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy
Autor: | Sachidananda Adiga M N, Usha Adiga, P B Nandith, Vijaya Shenoy |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Sodium chemistry.chemical_element Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) 030225 pediatrics Internal medicine Genotype Humans Medicine Glucuronosyltransferase Child business.industry Valproic Acid UGT2B7 Cross-Sectional Studies Endocrinology chemistry Pediatrics Perinatology and Child Health Trough level Population study Anticonvulsants Gene polymorphism Restriction fragment length polymorphism business 030217 neurology & neurosurgery |
Zdroj: | Indian Journal of Pediatrics. 88:764-770 |
ISSN: | 0973-7693 0019-5456 |
DOI: | 10.1007/s12098-020-03565-9 |
Popis: | To evaluate the pattern of UGT1A6 and UGT2B7 gene polymorphism in pediatric epileptic patients and to compare the sodium valproate concentration in different patterns of UGT gene polymorphism. In this cross-sectional study, 99 pediatric epileptic patients aged 2–18 y receiving Sodium valproate monotherapy for the past one month were included from JusticeK S Hegde Charitable hospital, Mangalore after obtaining informed consent. Genetic polymorphism patterns were evaluated by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Trough level serum valproate concentration was estimated by high-performance liquid chromatography (HPLC). Sodium valproate concentration in different UGT genotypes was compared by Analysis of Variance (ANOVA). P value |
Databáze: | OpenAIRE |
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