UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy

Autor: Sachidananda Adiga M N, Usha Adiga, P B Nandith, Vijaya Shenoy
Rok vydání: 2021
Předmět:
Zdroj: Indian Journal of Pediatrics. 88:764-770
ISSN: 0973-7693
0019-5456
DOI: 10.1007/s12098-020-03565-9
Popis: To evaluate the pattern of UGT1A6 and UGT2B7 gene polymorphism in pediatric epileptic patients and to compare the sodium valproate concentration in different patterns of UGT gene polymorphism. In this cross-sectional study, 99 pediatric epileptic patients aged 2–18 y receiving Sodium valproate monotherapy for the past one month were included from JusticeK S Hegde Charitable hospital, Mangalore after obtaining informed consent. Genetic polymorphism patterns were evaluated by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Trough level serum valproate concentration was estimated by high-performance liquid chromatography (HPLC). Sodium valproate concentration in different UGT genotypes was compared by Analysis of Variance (ANOVA). P value
Databáze: OpenAIRE
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