The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes
| Autor: | Saeed Veiskerami, Vahideh Assadollahi, Peyman Khosravi, Ahmad Cheraghi Venol, Hassan Ahmadvand, Reza Mohammadrezaei Khorramabadi, Shahrokh Bagheri |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology Physiology Glutathione peroxidase medicine.medical_treatment 030209 endocrinology & metabolism General Medicine Glutathione Pharmacology Malondialdehyde medicine.disease_cause Superoxide dismutase Glibenclamide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Physiology (medical) Alloxan biology.protein medicine Oxidative stress medicine.drug |
| Zdroj: | Archives of physiology and biochemistry. |
| ISSN: | 1744-4160 |
| Popis: | This study was conducted to evaluate the anti-diabetic and antioxidant effects of hydroalcoholic pomegranate peel extract (APE) in alloxan-induced diabetes rat models. We divided 60 rats into the following six equal groups (n = 10): Healthy control; diabetic control (100 mg/kg alloxan); sham + glibenclamide (10 mg/kg); diabetic + glibenclamide (10 mg/kg); sham + APE (200 mg/kg) and diabetic + APE (200 mg/kg). After 8 weeks, kidneys were taken out for biochemical and molecular studies. Following APE treatment, biochemical parameters including malondialdehyde (MDA), and glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) significantly induced in the treated group as compared with the control group (p < 0.05). Also, gene expression of GPx (3-fold), CAT (2.6-fold), and SOD (1.5-fold) were increased as compared to controls (p < 0.05). Overall, our results indicated that pomegranate can be used as an antioxidant agent to reduce complications from diseases associated with oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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