Results of Strontium-89 Therapy in Patients With Prostate Cancer Resistant to Chemotherapy
| Autor: | Nathan Better, Mark Rosenthal, Meir Lichtenstein, Dishan H. Gunawardana |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Palliative care medicine.medical_treatment Pain Antineoplastic Agents Cohort Studies Prostate cancer Refractory Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Bone Marrow Diseases Survival rate Aged Retrospective Studies Chemotherapy Leukopenia business.industry Palliative Care Prostatic Neoplasms Retrospective cohort study General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Thrombocytopenia Hormones Survival Rate Prostate-specific antigen Treatment Outcome Drug Resistance Neoplasm Strontium Radioisotopes Radiopharmaceuticals medicine.symptom business |
| Zdroj: | Clinical Nuclear Medicine. 29:81-85 |
| ISSN: | 0363-9762 |
| DOI: | 10.1097/01.rlu.0000109721.58471.44 |
| Popis: | Purpose: Strontium-89 (Sr-89) chloride is an effective palliative treatment of the bone metastases of prostate cancer. Chemotherapy has also been shown to have a palliative benefit in this disease. We aimed to determine the benefits and complications of Sr-89 therapy in patients with prostate cancer who had become refractory to chemotherapy. We conducted a retrospective review of 14 treatments administered to 13 patients with chemotherapy-resistant and hormone-resistant prostate cancer. Results: Of the 14 administered treatments, 8 (57%) resulted in improved pain control, with 2 patients able to stop analgesia. The median duration of response was 56 days. No prostate-specific antigen response was seen in the 8 patients tested. There was significant and prolonged bone marrow toxicity, with 6 patients requiring red blood cell transfusion. Prolonged thrombocytopenia was seen, with platelet counts remaining below baseline levels after treatment in all but one patient. Leukopenia was generally mild and not associated with infection. Conclusions: Sr-89 is an effective treatment of patients with chemotherapy-refractory prostate cancer, but careful and prolonged monitoring of hematologic parameters after therapy is required. |
| Databáze: | OpenAIRE |
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