Evaluation of Poly-N-Acetyl Glucosamine as a Hemostatic Agent in Patients Undergoing Cardiac Catheterization: A Double-Blind, Randomized Study
| Autor: | Nancy A. Healey, Samer F. Najjar, Christine M. Healey, Thomas McGarry, Shukri F. Khuri, Ban Khan, Hemant S. Thatte |
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| Rok vydání: | 2004 |
| Předmět: |
Erythrocyte Aggregation
Male Cardiac Catheterization medicine.medical_specialty medicine.medical_treatment Blood Loss Surgical Blood Pressure Femoral artery Postoperative Hemorrhage Administration Cutaneous Critical Care and Intensive Care Medicine Placebo Hemostatics Acetylglucosamine Double-Blind Method Heart Rate Catheterization procedure medicine.artery Pressure Humans Medicine Aged Cardiac catheterization business.industry Middle Aged Bandages Constriction Hemostasis Surgical Surgery Femoral Artery Treatment Outcome Clamp medicine.anatomical_structure Blood pressure Anesthesia Hemostasis Female business Artery |
| Zdroj: | Journal of Trauma: Injury, Infection & Critical Care. 57:S38-S41 |
| ISSN: | 0022-5282 |
| DOI: | 10.1097/01.ta.0000136749.20063.f0 |
| Popis: | Background: This is the first blinded, randomized, placebo-controlled clinical trial to evaluate the efficacy of poly-N-acetyl glucosamine (p-GLcNAc) in improving hemostasis in patients undergoing cardiac catheterization. Methods: Patients were randomly assigned to have either a placebo-treated (n = 17) or a p-GlcNAc-treated (n = 16) 3 x 3-cm patch topically placed at the femoral insertion site at the completion of their catheterization procedure with a mechanical pressure clamp applied over it. The amount of pressure was measured. Results: Although the placebo group had slightly higher clamp pressure applied to the femoral arterial puncture site at the end of the catheterization procedure (189 ± 47 vs. 149 ± 49 mm Hg,p = 0.042), the time to effective hemostasis (16 ± 7 vs. 10 ± 3 minutes, p = 0.01) was decreased in the p-GlcNAc group by 37%. Conclusion: The application of p-GlcNAc patches improved hemostasis at the arterial puncture site in patients undergoing cardiac catheterization. |
| Databáze: | OpenAIRE |
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