MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery

Autor: Stefano Seri, Antonella Cerquiglini, Peter Bill, A. Richard Walsh, J. Helen Cross, Paul L. Furlong, Amanda G. Wood, Elaine Foley, Ngoc Jade Thai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Drug Resistant Epilepsy
Neurology
Adolescent
Hemispheric dominance
Audiology
050105 experimental psychology
Lateralization of brain function
Functional Laterality
Neurosurgical Procedures
Functional mapping
03 medical and health sciences
0302 clinical medicine
Epilepsy surgery
medicine
Language lateralization
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Beamformers
Child
Children
Language
children
magnetoencephalography
language lateralization
hemispheric dominance
beamformers
functional mapping
epilepsy surgery
Original Paper
Brain Mapping
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
05 social sciences
Neuropsychology
Expressive language
Magnetoencephalography
Brain
Reproducibility of Results
Magnetic Resonance Imaging
Temporal Lobe
Frontal Lobe
Female
Neurology (clinical)
Anatomy
Functional magnetic resonance imaging
business
Cortical stimulation mapping
030217 neurology & neurosurgery
Zdroj: Brain Topography
Foley, E, Cross, J H, Thai, N J, Walsh, A R, Bill, P, Furlong, P, Wood, A G, Cerquiglini, A & Seri, S 2019, ' MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery ', Brain Topography, vol. 32, no. 3, pp. 492-503 . https://doi.org/10.1007/s10548-019-00703-1
ISSN: 1573-6792
0896-0267
Popis: Establishing language dominance is an important step in the presurgical evaluation of patients with refractory epilepsy. In the absence of a universally accepted gold-standard non-invasive method to determine language dominance in the preoperative assessment, a range of tools and methodologies have recently received attention. When applied to pediatric age, many of the proposed methods, such as functional magnetic resonance imaging (fMRI), may present some challenges due to the time-varying effects of epileptogenic lesions and of on-going seizures on maturational phenomena. Magnetoencephalography (MEG) has the advantage of being insensitive to the distortive effects of anatomical lesions on brain microvasculature and to differences in the metabolism or vascularization of the developing brain and also provides a less intimidating recording environment for younger children. In this study we investigated the reliability of lateralized synchronous cortical activation during a verb generation task in a group of 28 children (10 males and 18 females, mean age 12 years) with refractory epilepsy who were evaluated for epilepsy surgery. The verb generation task was associated with significant decreases in beta oscillatory power (13-30 Hz) in frontal and temporal lobes. The MEG data were compared with other available presurgical non-invasive data including cortical stimulation, neuropsychological and fMRI data on language lateralization where available. We found that the lateralization of MEG beta power reduction was concordant with language dominance determined by one or more different assessment methods (i.e. cortical stimulation mapping, neuropsychological, fMRI or post-operative data) in 89% of patients. Our data suggest that qualitative hemispheric differences in task-related changes of spectral power could offer a promising insight into the contribution of dominant and non-dominant hemispheres in language processing and may help to characterize the specialization and lateralization of language processes in children.
Databáze: OpenAIRE
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