A Biological Take on Halogen Bonding and Other Non-Classical Non-Covalent Interactions
| Autor: | P. Shing Ho, Alexander N. Ho, Ryan S. Czarny |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Models Molecular Halogen bond 010405 organic chemistry Hydrogen bond General Chemical Engineering Biomolecule Biomolecular engineering General Chemistry DNA 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Halogens chemistry Computational chemistry Group (periodic table) Halogen Materials Chemistry Non-covalent interactions Thermodynamics Pnictogen |
| Zdroj: | Chemical record (New York, N.Y.). 21(5) |
| ISSN: | 1528-0691 |
| Popis: | Classical hydrogen bonds have, for many decades, been the dominant non-covalent interaction in the toolbox that chemists and chemical engineers have used to design and control the structures of compounds and molecular assemblies as novel materials. Recently, a set of non-classical non-covalent (NC-NC) interactions have emerged that exploit the properties of the Group IV, V, VI, and VII elements of the periodic table (the tetrel, pnictogen, chalcogen, and halogen bonds, respectively). Our research group has been characterizing the prevalence, geometric constraints, and structure-function relationship specifically of the halogen bond in biological systems. We have been particularly interested in exploiting the biological halogen bonds (or BXBs) to control the structures, stabilities, and activities of biomolecules, including the DNA Holliday junction and enzymes. In this review, we first provide a set of criteria for how to determine whether BXBs or any other NC-NC interactions would have biological relevance. We then navigate the trail of studies that had led us from an initial, very biological question to our current point in the journey to establish BXBs as a tool for biomolecular engineering. Finally, we close with a perspective on future directions for this line of research. |
| Databáze: | OpenAIRE |
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