Prevalence of Active Long-term Problems in Patients With Anorectal Malformations: A Systematic Review
| Autor: | Stefano Giuliani, Laurie Rigueros Springford, Venediktos V Kapetanakis, Katie Jones, Martin J. Connor |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty Constipation Adolescent Urinary incontinence Subgroup analysis Cochrane Library 03 medical and health sciences Young Adult 0302 clinical medicine 030225 pediatrics medicine Prevalence Fecal incontinence Humans Young adult Urinary Bladder Neurogenic Chronic constipation business.industry Gastroenterology General Medicine Anorectal Malformations Sexual Dysfunction Physiological Sexual dysfunction Urinary Incontinence 030220 oncology & carcinogenesis medicine.symptom business Fecal Incontinence |
| Zdroj: | Diseases of the colon and rectum. 59(6) |
| ISSN: | 1530-0358 |
| Popis: | BACKGROUND: Anorectal malformations are a spectrum of congenital anomalies of the rectum with high infantile survival rates and variable outcomes. Long-term (>10 years old) active problems associated with this condition have been poorly investigated. OBJECTIVE: The purpose of this review was to systematically define the prevalence of the most common active long-term problems in patients with a history of anorectal malformation repair. DATA SOURCES: MEDLINE, EMBASE, and the Cochrane Library were searched electronically using the OVID search platform. STUDY SELECTION: Original articles from August 1, 1994, to October 20, 2015, that included outcome data for patients aged ≥10 years with anorectal malformation. Cloaca was excluded from the study. INTERVENTIONS: Prevalence estimates of anorectal malformations were obtained from published articles. CIs were ascertained in the logit scale after transforming prevalence into log odds and were then transformed into the original scale. The same method was used for subgroup analysis investigating high and low anorectal malformations. MAIN OUTCOME MEASURES: The overall prevalences of fecal, urinary, and sexual dysfunction were analyzed. RESULTS: Twelve studies including 455 patients with a history of anorectal malformation repair were included for analysis. The range of reported prevalence of long-term active problems was as follows: fecal incontinence, 16.7% to 76.7%; chronic constipation, 22.2% to 86.7%; urinary incontinence, 1.7% to 30.5%; ejaculatory dysfunction, 15.6% to 41.2%; and erectile dysfunction, 5.6% to 11.8%. LIMITATIONS: The study was limited by its retrospective, small size; multiple complex associated anomalies often not reported; and heterogeneous composition of patients with limited stratification analysis. CONCLUSIONS: There is an overall high prevalence of active long-term issues in adolescents and young adults with anorectal malformations. Additional multicenter research is needed to define characteristics and predictors of long-term outcome, to implement effective follow-up, and to transition to adult health care. |
| Databáze: | OpenAIRE |
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