Lacticaseibacillus rhamnosus TR08 alleviated intestinal injury and modulated microbiota dysbiosis in septic mice
| Autor: | Weiqin Li, Jiangtao Yin, Zhihui Tong, Wenjian Mao, Wen Sun, Lu Ke, Baiqiang Li, Xiaojia Xiao, Xianqiang Yu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Microbiology (medical) Gut microbiota Gut flora Microbiology law.invention Sepsis Mice Probiotic fluids and secretions Intestinal mucosa law medicine Animals Microecosystem Inflammation Bacteria Tight junction biology Lacticaseibacillus rhamnosus Probiotics Research medicine.disease biology.organism_classification QR1-502 Gastrointestinal Microbiome Immunoglobulin A Intestines Intestinal Diseases Immunology Dysbiosis Lacticaseibacillus rhamnosus TR08 |
| Zdroj: | BMC Microbiology, Vol 21, Iss 1, Pp 1-10 (2021) BMC Microbiology |
| ISSN: | 1471-2180 |
| DOI: | 10.1186/s12866-021-02317-9 |
| Popis: | Background Probiotics are widely used in intestinal microbiota imbalance caused by sepsis, however, the protective mechanism is still unclear. This study aimed to explore protective effect of Lacticaseibacillus rhamnosus TR08 on intestinal injury in septic mice. Results The levels of serum inflammatory factors were reduced significantly in septic mice treated with L. rhamnosus TR08. The levels of sIgA in terminal ileum were significantly higher in probiotic treatment group than sepsis group. Intestinal pathological damage in septic mice improved and the expression of tight junction proteins increased after probiotic treatment. Sequencing of fecal microbiota showed that the abundance and diversity of probiotic treatment group were significantly better than those of sepsis group, and beneficial bacteria increased while some bacteria decreased in the phylum level. Conclusion L. rhamnosus TR08 could improve the integrity of intestinal barrier, enhance the intestinal mucosal immunity in septic mice, and rebalance the intestinal microecosystem. |
| Databáze: | OpenAIRE |
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