Upregulation of miR-125b is associated with poor prognosis and trastuzumab resistance in HER2-positive gastric cancer
| Autor: | Dengjun Sun, Minghua Sui, Aihong Jiao, Huiyuan Zhai, Yong Wang, Yan Wang, Peng Li |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Cell 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Downregulation and upregulation Trastuzumab Internal medicine microRNA medicine Oncogene business.industry gastric cancer human epidermal growth factor receptor 2 Cancer microRNA-125b General Medicine Articles Cell cycle medicine.disease Molecular medicine trastuzumab 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis prognosis business medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | Gastric cancer is one of the most common types of human cancer associated with a poor prognosis. MicroRNAs (miRs), a class of non-coding RNAs that are 18-25 nucleotides in length, act as key regulators in gene expression, and have been implicated in various human cancer types. miR-125b has been implicated in the malignant progression of gastric cancer. However, the association between miR-125b expression, clinicopathological characteristics and trastuzumab resistance in human epidermal growth factor receptor 2 (HER2)-positive gastric cancer remains unclear. In the current study, in situ hybridization data demonstrated that 81.8% (108/132) of gastric cancer tissues exhibited positive expression of miR-125b, while only 26.3% (10/38) of non-tumor gastric tissues were miR-125b-positive. Reverse transcription-quantitative polymerase chain reaction data indicated that the expression level of miR-125b was markedly increased in gastric cancer tissues compared with non-cancerous gastric tissues. Furthermore, the miR-125b level was significantly associated with tumor (T) stage, lymph node metastasis, distant metastasis and TNM stage of gastric cancer (P |
| Databáze: | OpenAIRE |
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