Myocardial Injury in Critically Ill Children: A Case Control Study
| Autor: | Basheir A. Hassan, Mohamed H. Abdo, Mona M. Al Shafie, Saed M. Morsy, Al Shaymaa Ali, Ahmad M. Hassaneen, Ahmed G. Siam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pediatric intensive care unit
medicine.medical_specialty Pediatrics Cardiac troponin Troponin T Article Subject Critically ill business.industry Case-control study macromolecular substances Disease severity Internal medicine medicine Cardiology Breathing Clinical Study Left Ventricular Fractional Shortening business |
| Zdroj: | ISRN Cardiology |
| ISSN: | 2090-5599 2090-5580 |
| Popis: | Objectives. The aim of this study was to investigate the occurrence of myocardial injury in critically ill children through assessment of cardiac troponin T levels and whether levels are associated with disease severity and myocardial dysfunction measured by echocardiography. Methods. Over a 6-month period, this case control study included 50 patients admitted to Pediatric Intensive Care Unit of Zagazig University Children’s Hospital. Twenty-five healthy children were included as a control group. Demographic and clinical data including the pediatric index of mortality II score were recorded. Echocardiographic examination was done and level of cardiac troponin T was measured using Elecsys Troponin T STAT Immunoassay. Results. Cardiac troponin T levels were significantly higher in critically ill in comparison to healthy children (median 22 (18–28) pg/mL versus 10 (10-10) pg/mL, P<0.05). Cardiac troponin T levels correlated positively with duration of ventilation as well as with disease severity and correlated negatively with left ventricular fractional shortening. Moreover, cardiac troponin T levels were significantly higher in nonsurvivors when compared to survivors (median 34.5 (27.5–41.5) pg/mL versus 20 (18–24) pg/mL, P<0.05). Conclusion. In critically ill children, cardiac troponin T levels were elevated and were associated with duration of ventilation and disease severity. |
| Databáze: | OpenAIRE |
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