Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis
| Autor: | Josep Maria Cruzado Garrit, Juan Torras Ambros, Xavier Fulladosa Oliveras, Laura Martinez Valenzuela, Juliana Draibe, Maria Quero Ramos, Edoardo Melilli |
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| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Proteïnúria Physiology 030232 urology & nephrology lcsh:Medicine Urine Pathology and Laboratory Medicine Kidney Kidney Function Tests urologic and male genital diseases Gastroenterology Biochemistry Cohort Studies chemistry.chemical_compound 0302 clinical medicine fluids and secretions Medicine and Health Sciences lcsh:Science Multidisciplinary Proteinuria Kidney diseases biology Incidence (epidemiology) Remission Induction Biochemical markers Middle Aged Prognosis Body Fluids Treatment Outcome Creatinine Marcadors bioquímics Female medicine.symptom Anatomy Vasculitis Research Article Glomerular Filtration Rate medicine.medical_specialty Pronòstic mèdic Inflammatory Diseases Immunology Renal function Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Autoimmune Diseases 03 medical and health sciences Signs and Symptoms Rheumatology Diagnostic Medicine Internal medicine medicine Humans Aged 030203 arthritis & rheumatology Renal Physiology business.industry lcsh:R C-reactive protein Biology and Life Sciences Kidneys Renal System medicine.disease chemistry ROC Curve biology.protein Malalties del ronyó lcsh:Q Clinical Immunology Calprotectin Clinical Medicine business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname PLoS ONE Dipòsit Digital de la UB Universidad de Barcelona PLoS ONE, Vol 13, Iss 10, p e0205982 (2018) |
| Popis: | Background Calprotectin is produced by neutrophils and macrophages, and released during the acute phase of the ANCA vasculitis. The aim of our study was to determine if serum and urine calprotectin are disease activity and prognosis biomarkers in ANCA vasculitis patients during remission. Methods Forty-two ANCA vasculitis patients were included. Twenty-seven patients were in remission phase under immunosuppressive therapy, and 15 patients were in the acute phase. Four healthy controls were included. We determined calprotectin in serum and urine samples at the time of the inclusion. We recorded the incidence of relapse and the evolution of GFR, proteinuria, hematuria, and C reactive protein and ANCA titer during 24 months of follow-up. Results In remission phase, serum calprotectin was higher than in healthy controls but lower compared to acute patients (p = 0.05). Serum calprotectin at inclusion was higher in patients who increased proteinuria during follow-up (p = 0.04), with hematuria (p = 0.08), and with non-decreasing ANCA titer (p = 0.0019). Serum calprotectin at inclusion in stable patients who subsequently decreased GFR during follow-up was higher compared with those with a stable or improving GFR (p = 0.03). Urine calprotectin was lower in patients with sclerotic histology in remission (p = 0.03) and acute phase (p = 0.12) compared to the rest of histologies. Conclusions Worsening of renal function, hematuria, rising proteinuria and non-decreasing ANCA correlated with higher levels of serum calprotectin at recruitment. Low urine calprotectin was found in patients with sclerotic histology. Calprotectin during remission in ANCA vasculitis may be useful to identify subclinical inflammation and worse renal prognosis patients. |
| Databáze: | OpenAIRE |
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