Gold nanoparticles–biomembrane interactions: From fundamental to simulation
| Autor: | Shengyang Yang, Yusheng Mao, Shasha Sun, Chen Zhou, Emmanuel Okoampah |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
010304 chemical physics Biocompatibility Simulation modelling Metal Nanoparticles Nanotechnology 02 engineering and technology Surfaces and Interfaces General Medicine Phototherapy 021001 nanoscience & nanotechnology 01 natural sciences Nanomaterials Drug Delivery Systems Nanomedicine Colloid and Surface Chemistry Colloidal gold 0103 physical sciences Drug delivery Gold Surface charge Physical and Theoretical Chemistry 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 196:111312 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2020.111312 |
| Popis: | Gold Nanoparticles (AuNPs) are a class of promising nanomaterial for biomedical applications ranging from bioimaging, drug delivery to phototherapy because of their biocompatibility, easily tunable size and shape, and versatile surface modifications. In recent years, the rapid development of AuNPs in nanomedicine has made it imperative to seek fundamental understanding on their nano-biointeractions to minimize adverse effects and improve targeting/imaging efficiency. In this review, we summarize the different pathways of NPs-biomembrane interactions with a focus on AuNPs, follow by an analysis on how the physiochemical properties (size, surface charge, shape, surface ligands, and hydrophobicity etc.) of AuNPs can be involved in the mechanisms of cellular uptake. Finally, some recent advances on simulation modelling of AuNPs-biomembrane interactions and a brief outlook in the field are discussed. |
| Databáze: | OpenAIRE |
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