COMBINATION TREATMENT WITH INTRAVITREAL INJECTION OF RANIBIZUMAB AND REDUCED FLUENCE PHOTODYNAMIC THERAPY FOR CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS
| Autor: | Erdal Yuzbasioglu, Rifat Rasier, Amber Şenel, Alper Şengül, Özgür Artunay, Halil Bahcecioglu |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Visual acuity genetic structures medicine.medical_treatment Visual Acuity Photodynamic therapy Antibodies Monoclonal Humanized Neovascularization chemistry.chemical_compound Ranibizumab Ophthalmology medicine Humans Prospective Studies Fluorescein Angiography Pseudoxanthoma Elasticum Prospective cohort study Aged business.industry Retinal General Medicine Middle Aged medicine.disease Combined Modality Therapy Choroidal Neovascularization eye diseases Angioid streaks Treatment Outcome Choroidal neovascularization Photochemotherapy chemistry Intravitreal Injections Angioid Streaks Female sense organs medicine.symptom business Tomography Optical Coherence Follow-Up Studies medicine.drug |
| Zdroj: | Retina. 31:1279-1286 |
| ISSN: | 0275-004X |
| DOI: | 10.1097/iae.0b013e318205b228 |
| Popis: | BACKGROUND To evaluate combination treatment with intravitreal ranibizumab injection and reduced fluence photodynamic therapy for choroidal neovascularization associated with angioid streaks. METHODS This is an interventional case series of 10 previously untreated eyes of 10 patients with choroidal neovascularization secondary to angioid streaks. All eyes were treated with reduced fluence photodynamic therapy using 25 J/cm, immediately followed by intravitreal ranibizumab injection at baseline, and subsequent injections were performed on an as-needed basis thereafter. Treatment efficacy was assessed based on best-corrected visual acuity and optical coherence tomography findings. RESULTS After 12 months of follow-up, the best-corrected visual acuity improved by >2 lines in 6 eyes (60%), remained within 2 lines of baseline in 3 eyes (30%), and decreased by ≥ 3 lines in only 1 eye (10%). The mean central foveal thickness decreased significantly from 332.2 μm at baseline to 235.7 μm at the last follow-up (P < 0.001), as measured by optical coherence tomography. CONCLUSION The preliminary results of this prospective study indicate that combination treatment with intravitreal ranibizumab injection and reduced fluence photodynamic therapy for choroidal neovascularization associated with angioid streaks seems to be effective in reducing or eliminating retinal edema, regression of neovascularization, and improving or stabilizing visual acuity without any complications. Large controlled studies are needed to evaluate the long-term effects of this combination regimen. |
| Databáze: | OpenAIRE |
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