Current concepts in the immunopathogenesis of psoriasis
| Autor: | James G. Krueger, Michelle A. Lowes, Wook Lew |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
CD3 medicine.medical_treatment Population Dermatology Sensitivity and Specificity Immune system Immunotoxin Psoriasis medicine Animals Humans education education.field_of_study biology business.industry Biopsy Needle Interleukin Prognosis medicine.disease Immunohistochemistry Immunity Innate Rats Disease Models Animal Cytokine Immunology Disease Progression biology.protein Cytokines Female business CD8 |
| Zdroj: | Dermatologic Clinics. 22:349-369 |
| ISSN: | 0733-8635 |
| DOI: | 10.1016/j.det.2004.03.010 |
| Popis: | Psoriasis vulgaris affects approximately 2% of the US population, and although it varies in severity, it imposes a great burden on those who have this disease. Psoriasis was initially considered to be a primary disorder of keratinocytes, with disturbed epidermal differentiation leading to keratinocyte hyperproliferation. Now there is much evidence to support the involvement of the immune system in the pathogenesis and maintenance of psoriasis, including roles for CD8 + and CD4 + lymphocytes, dendritic cells (DCs), monocytes/macrophages, and natural killer (NK) and natural killer T (NK-T) cells. Keratinocytes may still play an integral role, responding to the leukocyte infiltration and cytokine environment. Novel anti–T-lymphocyte immunotherapies, and review of the mechanisms of some traditional antipsoriatic medications, have confirmed an important role of the immune system in psoriasis (reviewed in reference [1]). Therapies aimed at different immune targets have proved successful, although there is variability in clinical response between patients, reflecting the complexity of psoriasis pathogenesis and redundancy of immune pathways. The first such treatment used the immunotoxin DAB389IL-2, which is a fusion protein carrying a cellular toxin to interleukin 2R (IL-2R)–expressing cells [2] .T his agent blocks proliferation of activated lymphocytes, and clinical improvement was associated with reduction in intraepidermal CD3 + and CD8 + Tc ells |
| Databáze: | OpenAIRE |
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