Four-agent induction/consolidation therapy for childhood acute lymphoblastic leukemia: an Indian experience
| Autor: | Tapan K. Saikia, V. R. Pai, Purna Kurkure, R. S. Lyer, Nadkarni Ks, Gopal R, Nair Cn, Suresh K. Pai, Suresh H. Advani |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Vincristine medicine.medical_treatment Prednisolone India Acute lymphocytic leukemia Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Childhood Acute Lymphoblastic Leukemia Chemotherapy business.industry Remission Induction Cytarabine Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Prognosis Surgery Regimen Doxorubicin Child Preschool Multivariate Analysis Female Complication business medicine.drug |
| Zdroj: | American journal of hematology. 39(4) |
| ISSN: | 0361-8609 |
| Popis: | During 1984-1986, a total of 128 children with acute lymphoblastic leukemia (ALL) were treated with an induction-consolidation regimen consisting of doxorubicin, vincristine, cytosine-arabinoside, and prednisolone. One hundred two (80%) patients belonged to high-risk group. The complete remission rate for all the patients was 91%. The event-free survival at 5 years was 32.0% ± 23%. On multivariate analysis the event-free survival and disease-free survival was not altered by age, sex, WBC count, platelet count, LDH level, and surface phenotype. Infection due to prolonged marrow aplasia was a common complication, leading to mortality of 8 patients during induction and 33 patients during first remission. The relapse rate has been 36% (42 patients). The predominance of high-risk ALL in the Indian population underscores the need for intensive therapy. Improved supportive care during induction and remission seems essential to decrease therapy-related mortality, leading to improved survival. |
| Databáze: | OpenAIRE |
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