Central pathology review of salivary gland adenoid cystic carcinoma
Autor: | Makoto Urano, Hiroshi Inagaki, Toshitaka Nagao, Ken-ichi Nibu, Tetsuro Onitsuka, Hideaki Hirai, Hidetaka Yamamoto, Yasushi Fujimoto, Toru Nagao, Kazuo Sakurai, Yuichiro Tada, Kiyoaki Tsukahara, Naohito Hato, Ryo Kawata, Kenji Okami, Daisuke Kawakita, Kimihide Kusafuka, Ken Ichi Taguchi, Masato Nakaguro, Kaori Ueda, Nobuhiro Hanai, Satoshi Kano, Takayuki Murase, Ayako Masaki |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Adenoma Pleomorphic Basal cell adenoma Central Pathology Review Salivary Glands Pleomorphic adenoma 03 medical and health sciences 0302 clinical medicine Japan medicine Humans Pathological Retrospective Studies Salivary gland business.industry Salivary Gland Neoplasms medicine.disease Carcinoma Adenoid Cystic Salivary Gland Adenoid Cystic Carcinoma 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Cribriform Adenocarcinoma business |
Zdroj: | Head & Neck. 42:1721-1727 |
ISSN: | 1097-0347 1043-3074 |
Popis: | Background To assess the role of a central pathology review in the diagnosis of salivary gland adenoid cystic carcinoma (AdCC). Methods Surgically resected salivary gland tumors diagnosed as AdCC (n = 219) in 15 reference hospitals in Japan were subjected to a retrospective pathological re-evaluation. Results After the review, the AdCC diagnosis was revised in 21/219 cases (9.6%). The six benign tumors (2.7%) comprised five basal cell adenomas and one pleomorphic adenoma, and among these six patients, three received postoperative radiotherapy. The remaining 15 malignant tumors (6.8%) comprised nine basal cell adenocarcinomas and six other carcinomas. All revised basal cell adenoma/adenocarcinoma cases were of rare cribriform variants. Conclusions A significant proportion of AdCC pathology reports were revised after the central pathology review. It should be emphasized that the greatest attention should be paid in differentiating AdCC from cribriform variant basal cell adenoma/adenocarcinoma, which is very rare in salivary gland tumors. |
Databáze: | OpenAIRE |
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