Disseminated extracranial metastatic meningioma
| Autor: | Chee K. Tham, Sharon Y.Y. Low, Colum P. Nolan, Chin Fong Wong, Cristine Ding, Felicia H. Z. Chua |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Oncology Anaplastic Meningioma medicine.medical_specialty Pathology Bevacizumab Angiogenesis Inhibitors Disease Metastasis Meningioma 03 medical and health sciences Fatal Outcome 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans In patient Neoplasm Metastasis Brain Neoplasms business.industry Metastatic Meningioma General Medicine Prognosis medicine.disease Neurology 030220 oncology & carcinogenesis Female Surgery Neurology (clinical) Patient report business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Clinical Neuroscience. 33:214-216 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2016.01.038 |
| Popis: | Meningiomas are usually low-grade, solitary lesions that rarely metastasize. In this group of central nervous system tumours, the higher grade subtypes are notorious for resistance to conventional chemo-radiation therapies. Recent studies have shown efficacy in the use of bevacizumab in patients with recurrent and, or progressive anaplastic meningioma. The authors report a case of a young patient with recurrent anaplastic meningioma who despite being treated with bevacizumab, progressed with disease dissemination to multiple extracranial sites. Although the majority of meningiomas are amendable to treatment, the higher grade subtypes remain therapeutically challenging. The unexpected resistance to anti-angiogenic therapy in this patient adds another layer of complexity to an elusive subset of a supposedly benign disease. This patient report reflects the need for in-depth studies, molecular characterization and overall, better disease understanding in order to improve prognosis for affected patients. |
| Databáze: | OpenAIRE |
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