Modulation of nuclear receptor activity by the F domain
| Autor: | Debra F. Skafar, Shivali Patel |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Chemistry
Protein Conformation Estrogen receptor Estrogens Biochemistry Molecular biology Estrogen Receptor Antagonists Cell biology Protein Structure Tertiary Estrogen-related receptor alpha Endocrinology Nuclear receptor Receptors Estrogen Humans Estrogen-related receptor gamma Molecular Biology Estrogen receptor alpha Estrogen receptor beta PELP-1 Protein Binding |
| Zdroj: | Molecular and cellular endocrinology. |
| ISSN: | 1872-8057 |
| Popis: | The F domain located at the C-terminus of proteins is one of the least conserved regions of the estrogen receptors alpha and beta, members of the nuclear hormone receptor superfamily. Indeed, many members of the superfamily lack the F domain. However, when present, removing the F domain entirely or mutating it alters transactivation, dimerization, and the responses to agonist and antagonist ligands. This review focuses on the functions of the F domain of the estrogen receptors, particularly in relation to other members of the superfamily. |
| Databáze: | OpenAIRE |
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