Pharmacological Profiles of High-Concentration (20 μg/g) Tacalcitol Ointment: Effects on Cutaneous Inflammation, Epidermal Proliferation, and Differentiation in Mice
| Autor: | Satoshi Asano, Tomohiro Ohta, Hideko Takagi, Hiroaki Sato, Junko Hata, Yasuhiro Ogino, Keiji Komoriya |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Tissue transglutaminase Administration Topical Dermatitis Dermatology Drug Administration Schedule Ornithine decarboxylase Ointments Mice chemistry.chemical_compound Reference Values Psoriasis Internal medicine medicine Animals skin and connective tissue diseases Calcipotriol Mice Hairless Dose-Response Relationship Drug integumentary system biology Tacalcitol business.industry Biopsy Needle General Medicine medicine.disease Immunohistochemistry Betamethasone valerate eye diseases Hairless body regions Disease Models Animal stomatognathic diseases Treatment Outcome Endocrinology chemistry Myeloperoxidase Dihydroxycholecalciferols biology.protein Female Epidermis business medicine.drug |
| Zdroj: | The Journal of Dermatology. 30:510-524 |
| ISSN: | 0385-2407 |
| DOI: | 10.1111/j.1346-8138.2003.tb00425.x |
| Popis: | This study focused on the effects of tacalcitol (1,24 (R) (OH)2D3, TV-02) ointment (20 micro g/g) on cutaneous inflammation, epidermal proliferation, and differentiation and compared them with tacalcitol ointment (2 micro g/g) and other anti-psoriatic ointments using hairless mice. Tacalcitol ointment (0, 2 and 20 micro g/g) significantly inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cutaneous inflammation, histopathologically. The effect of tacalcitol ointment (20 micro g/g) on cutaneous inflammation was much stronger than that of tacalcitol ointment (0, 2 micro g/g), and as effective as calcipotriol ointment (50 micro g/g) or betamethasone valerate ointment (1.2 mg/g). Tacalcitol ointment (20 micro g/g) also significantly inhibited TPA-induced myeloperoxidase (MPO) activity, as effectively as calcipotriol ointment (50 micro g/g) or betamethasone valerate ointment (1.2 mg/g). The effect of tacalcitol ointment on epidermal proliferation [ornithine decarboxylase (ODC) activity] and differentiation [transglutaminase (TGase) activity] was dose-dependent from 0 micro g/g to 20 micro g/g. The effect of tacalcitol ointments on epidermal proliferation was significant at the doses of 2 micro g/g and 20 micro g/g, and that on epidermal differentiation was significant at the doses of 0.2 micro g/g or more. The effect of tacalcitol ointment (20 micro g/g) on epidermal differentiation was significantly stronger than tacalcitol ointment (2 micro g/g). In this study, tacalcitol ointment (20 micro g/g) was found to have a marked effect on cutaneous inflammation and improved effect on epidermal differentiation, although tacalcitol ointment (2 micro g/g) also had significant effects on epidermal proliferation and differentiation. These findings support the clinical effectiveness of tacalcitol ointment (20 micro g/g) against psoriasis. |
| Databáze: | OpenAIRE |
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