Alteration of cortico-limbic-striatal neural system in major depressive disorder and bipolar disorder
| Autor: | Qian Zhou, Shengnan Wei, Yifang Zhou, Wenhui Cui, Lingtao Kong, Yuning Zhou, Fei Wang, Miao Chang, Feng Wu, Haiyang Geng, Ye Wang, Elliot Kale Edmiston, Xu Dai, Ke Xu, Xiaowei Jiang, Yanqing Tang, Dahai Wang |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent Prefrontal Cortex computer.software_genre behavioral disciplines and activities Lateralization of brain function 03 medical and health sciences Young Adult 0302 clinical medicine Voxel mental disorders medicine Limbic System Humans Bipolar disorder Young adult Psychiatry Depressive Disorder Major Resting state fMRI Middle Aged medicine.disease Magnetic Resonance Imaging Corpus Striatum 030227 psychiatry Psychiatry and Mental health Clinical Psychology Mood Major depressive disorder Female Abnormality Psychology computer Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of affective disorders. 221 |
| ISSN: | 1573-2517 |
| Popis: | Background It is often difficult to differentiate major depressive disorder (MDD) and bipolar disorder (BD) merely according to clinical symptoms. Similarities and differences in neural activity between the two disorders remain unclear. In current study, we use amplitude of low-frequency fluctuations (ALFF) to compare neural activation changes between MDD and BD patients. Methods One hundred and eighty-three adolescents and young adults (57 MDD, 46 BD and 80 healthy controls, HC) were scanned during resting state. The ALFF for each participant was calculated, and were then compared among all groups using voxel-based analysis. Results There was a significant effect of diagnosis in the core regions of cortico-limbic-striatal neural system. Furthermore, MDD showed left-sided abnormal neural activity while BD showed a bilateral abnormality in this neural system. Limitations This study was underpowered to consider medications, mood states and neural developmental effects on the neural activation. Conclusions Differences in lateralization of ALFF alterations were found. Alterations predominated in the left hemisphere for MDD, whereas alterations were bilateral for BD. |
| Databáze: | OpenAIRE |
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