Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus

Autor: Beenita Saikia, D. C. Pathak, Chandana Choudhury Barua, Kunjbihari Sulakhiya, Prakash Haloi, Hooriah Rizavi, Shantanu Tamuli, Xinguo Ren
Rok vydání: 2018
Předmět:
Lipopolysaccharides
Male
Zanthoxylum
0301 basic medicine
Imipramine
Anti-Inflammatory Agents
Pharmaceutical Science
Pharmacology
Hippocampus
Eating
Mice
0302 clinical medicine
Drug Discovery
Behavior
Animal
biology
Depression
General Medicine
Antidepressive Agents
serotonin
Seeds
Cytokines
Molecular Medicine
dopamine
Inflammation Mediators
medicine.drug
Context (language use)
Motor Activity
norepinephrine
Lethal Dose 50
03 medical and health sciences
Dopamine
medicine
Animals
Hexanes
Biogenic Monoamines
Neuroinflammation
Inflammation
Brain-derived neurotrophic factor
Plants
Medicinal
Plant Extracts
Brain-Derived Neurotrophic Factor
lcsh:RM1-950
Feeding Behavior
biology.organism_classification
Disease Models
Animal
Oxidative Stress
lcsh:Therapeutics. Pharmacology
030104 developmental biology
Monoamine neurotransmitter
Complementary and alternative medicine
Solvents
Serotonin
030217 neurology & neurosurgery
Phytotherapy
Zdroj: Pharmaceutical Biology, Vol 56, Iss 1, Pp 245-252 (2018)
ISSN: 1744-5116
1388-0209
DOI: 10.1080/13880209.2017.1391298
Popis: Context: Depression is an inflammatory, commonly occurring and lethal psychiatric disorder having high lifetime prevalence. Zanthoxylum alatum Roxb. (Rutaceae), commonly called Timur, has high medicinal value and is used ethnomedicinally for the treatment of various diseases. Objective: To evaluate the effect of hexane extract of Z. alatum seeds (ZAHE) on lipopolysaccharide (LPS)-induced depression-like behaviour in Swiss albino mice. Materials and methods: Mice were treated with ZAHE (100 and 200 mg/kg, p.o.) and imipramine (10 mg/kg injected i.p.) for 14 days. On 14th day of the treatment, depression-like behaviour was induced by LPS (0.83 mg/kg injected i.p.) and after 24 h of LPS administration, it was assessed by measuring behavioural parameters and biochemical estimations. Results: Behavioural tests, including the open field test, forced swimming test, tail suspension test and sucrose preference test revealed that ZAHE (100 and 200 mg/kg, p.o.) and imipramine (10 mg/kg injected i.p.) alleviated the depression symptoms of LPS-induced mice. Moreover, ZAHE treatments reversed the LPS-induced alterations in the concentrations of norepinephrine and serotonin (5-HT) and inhibited the expression of brain-derived neurotrophic factor, pro-inflammatory cytokines and oxido-nitrosative stress in the mice. Acute toxicity was calculated to be LD50 > 2500 mg/kg. Discussion and conclusions: This study showed that LPS-induced depression in mice was significantly prevented by ZAHE at both the dosages. In conclusion, ZAHE exhibited an antidepressant activity by altering monoaminergic neurotransmitters in the brain combined with its anti-inflammatory potential. Thus, it could be an effective therapeutic against inflammation-induced depression and other brain disorders.
Databáze: OpenAIRE
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