Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: A review
| Autor: | Jean-Marc Crowet, Laurence Lins, Magali Deleu, Mehmet Nail Nasir |
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| Přispěvatelé: | Laboratory of Molecular Biophysics at Interfaces (LBMI), Gembloux Agro-Bio Tech, University of Liege |
| Rok vydání: | 2014 |
| Předmět: |
Tilted peptide
Bioactive molecules Biophysics Biochemistry Cell membrane Molecular dynamics Biobased molecule High complexity medicine ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification Chemistry Drug discovery Biomolecule Molecular biophysics Cell Biology [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biophysics Lipid-specific interaction Cyclic lipopeptide medicine.anatomical_structure Membrane Molecular modeling and dynamics |
| Zdroj: | Biochimica et Biophysica Acta:Biomembranes Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2014, 1838 (12), pp.3171-3190. ⟨10.1016/j.bbamem.2014.08.023⟩ |
| ISSN: | 0005-2736 1879-2642 |
| DOI: | 10.1016/j.bbamem.2014.08.023 |
| Popis: | Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic structures. The interactions between bioactive molecules and lipids are important for numerous processes, from drug bioavailability to viral fusion. The cell membrane is a carefully balanced environment and any change inflicted upon its structure by a bioactive molecule must be considered in conjunction with the overall effect that this may have on the function and integrity of the membrane. Conceptually, understanding the molecular mechanisms by which bioactive molecules interact with cell membranes is of fundamental importance.Lipid specificity is a key factor for the detailed understanding of the penetration and/or activity of lipid-interacting molecules and of mechanisms of some diseases. Further investigation in that way should improve drug discovery and development of membrane-active molecules in many domains such as health, plant protection or microbiology.In this review, we will present complementary biophysical approaches that can give information about lipid specificity at a molecular point of view. Examples of application will be given for different molecule types, from biomolecules to pharmacological drugs. A special emphasis is given to cyclic lipopeptides since they are interesting molecules in the scope of this review by combining a peptidic moiety and a lipidic tail and by exerting their activity via specific interactions with the plasma membrane. |
| Databáze: | OpenAIRE |
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