Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal
| Autor: | Madhab Lamsal, Saroj Khatiwada, Sharad Gautam, Lalit Narayan Chaudhary, Nirmal Baral, Hanoon P Pokharel, Basanta Gelal |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine endocrine system medicine.medical_specialty endocrine system diseases medicine.medical_treatment Thyrotropin chemistry.chemical_element Urine 030105 genetics & heredity Iodine Thyroglobulin Young Adult 03 medical and health sciences Hypothyroidism Nepal Thyroid-stimulating hormone Pregnancy Internal medicine medicine Humans Autoantibodies business.industry General Medicine medicine.disease Thyroid Diseases Iodine deficiency Anti-thyroid autoantibodies Pregnancy Complications Thyroxine Cross-Sectional Studies Endocrinology chemistry Female Thyroid function business |
| Zdroj: | Journal of Nepal Health Research Council. 15:114-119 |
| ISSN: | 1999-6217 1727-5482 |
| DOI: | 10.3126/jnhrc.v15i2.18182 |
| Popis: | Background: Iodine deficiency, thyroid dysfunction and development of thyroid autoimmunity during pregnancy may affect mother and the developing fetus. This study was carried out to find iodine status, thyroid dysfunction and thyroid autoimmunity among pregnant women.Methods: Ninety two pregnant women from three districts of eastern Nepal (Sunsari, Morang and Jhapa) were enrolled for the study, and urine and blood samples were collected. Urinary iodine concentration (UIC), free thyroxine (free T4), thyroid stimulating hormone (TSH), thyroglobulin and anti-thyroid peroxidase (TPO) antibody levels were estimated.Results: The median UIC, mean free T4 and TSH, median thyroglobulin and anti-TPO antibody in the pregnant women were 282.2 (158.42-376) μg/L, 1.14±0.41 ng/dL, 4.57±2.56 IU/mL, 6.5 (4.0-11.0) ng/mL, 1.52 (0.97-2.23) IU/mL respectively. In sufficient (40 ng/mL) and positive anti-TPO antibody was observed in three (3.26%) women for both.Conclusions: Iodine intake was sufficient among pregnant women recently, however, chronic iodine deficiency persisted in small fraction of pregnant women. Mild thyroid dysfunction was common, and thyroid autoimmunity was present in small portion of Nepalese pregnant women population.Keywords: Anti-thyroid peroxidase antibody; Iodine deficiency; Nepal; pregnant women; thyroid dysfunction. |
| Databáze: | OpenAIRE |
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