INHALATION OF PENICILLIN DUST

Autor: Mary Karp, Louis Krasno, Paul S. Rhodes
Rok vydání: 1948
Předmět:
Zdroj: Journal of the American Medical Association. 138:344
ISSN: 0002-9955
DOI: 10.1001/jama.1948.02900050012004
Popis: In view of the favorable reports in recent literature on the inhalation of therapeutic agents, especially penicillin, and because of the many possibilities of the method, we have attempted to produce even greater and more protracted topical effectiveness by a method which involves the inhalation of the fine dust aerosol particles. This method has simplified the mechanics of aerosol therapy, thus expanding its scope more readily for office and home treatment. Apparatus used for inhalation therapy in the past has been based on the delivery of the aerosol vapor under positive pressure of oxygen or air by means of a hand bulb or oxygen tank and gauge. The principle utilized in the new method is based on the negative pressure created by normal breathing during the inspiratory phase. Inhaling penicillin dust in this manner is more physiological and permits a more even and perhaps a wider distribution of medicament throughout the respiratory tract. The patient is not required to manipulate an exhaling valve during the expiration phase, and the cumbersome equipment of oxygen tank and gauge is unnecessary. The inhalation of thle dust particles yields a greater effect than the vapor, because there is greater concentration of penicillin per unit area and because the penicillin must go into solution while in contact with mucous membrane before it can be absorbed. The penicillin dust used in this study was crystalline sodium penicillin' processed to 50-100-mesh particles. This wasfound to be less hydroscopic than the sodium penicillin salt and could be stored at room temperature, without losing its potency, moreexeadily than the penicillin liquid which was used as the nebulin for the vapor method.
Databáze: OpenAIRE
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