Topical delivery of salicylates
| Autor: | Choon Fu Goh, Soo Chin Yeoh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
media_common.quotation_subject Keratolytic Pain relief Anti-Inflammatory Agents Pharmaceutical Science 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Keratolytic Agents Pharmacokinetics Topical salicylic acid Medicine media_common Skin business.industry 021001 nanoscience & nanotechnology chemistry History of use 0210 nano-technology business Salicylic Acid Salicylic acid Methyl salicylate |
| Zdroj: | Drug delivery and translational researchReferences. 12(5) |
| ISSN: | 2190-3948 |
| Popis: | Salicylates have a long history of use for pain relief. Salicylic acid and methyl salicylate are among the widely used topical salicylates namely for keratolytic and anti-inflammatory actions, respectively. The current review summarises both passive and active strategies, including emerging technologies employed to enhance skin permeation of these two salicylate compounds. The formulation design of topical salicylic acid targets the drug retention in and on the skin based on the different indications including keratolytic, antibacterial and photoprotective actions, while the investigations of topical delivery strategies for methyl salicylate are limited. The pharmacokinetics and metabolisms of both salicylate compounds are discussed. The current overview and future perspectives of the topical delivery strategies are also highlighted for translational considerations of formulation designs. |
| Databáze: | OpenAIRE |
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