Bioconcentration and Metabolic Effects of Emerging PFOS Alternatives in Developing Zebrafish
| Autor: | Daniel J. Kostyniuk, Jan A. Mennigen, Christine Hum, Yuanxiang Jin, Wenqing Tu, Laia Navarro-Martín, Jing Huang, Hing Man Chan, Ruben Martinez, Mi Deng |
|---|---|
| Přispěvatelé: | European Commission, Martínez, Rubén, Navarro-Martín, Laia, Martínez, Rubén [0000-0001-9965-7042], Navarro-Martín, Laia [0000-0001-6554-8833] |
| Rok vydání: | 2019 |
| Předmět: |
Bioconcentration
010501 environmental sciences 01 natural sciences Toxins Animals Humans Environmental Chemistry Zebrafish 0105 earth and related environmental sciences Binding affinities Fluorocarbons biology Chemistry Chinese market General Chemistry biology.organism_classification Bioaccumulation Metabolisme Molecular Docking Simulation Metabolic pathway Metabolism Alkanesulfonic Acids Energy expenditure Toxines Metabolic effects Environmental chemistry Water Pollutants Chemical |
| Zdroj: | Environmental Science & Technology Digital.CSIC. Repositorio Institucional del CSIC instname Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1520-5851 0013-936X |
| DOI: | 10.1021/acs.est.9b03820 |
| Popis: | The novel PFOS alternatives, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS), are emerging in the Chinese market, but little is known about their ecological risks. In this study, zebrafish embryos were exposed to PFOS, F-53B, and OBS to evaluate their bioconcentration and acute metabolic consequences. Per- and polyfluoroalkyl substances (PFASs) accumulated in larvae in the order of F-53B > PFOS > OBS, with the bioconcentration factors ranging from 20 to 357. Exposure to F-53B and PFOS, but not OBS, increased energy expenditure, and reduced feed intake in a concentration-dependent manner and the expression of genes involved in metabolic pathways at the transcriptional and translational levels. Molecular docking revealed that the binding affinities of PFASs to glucokinase were decreased in the following order: F-53B > PFOS > OBS. Finally, the results of Point of Departure (PoD) indicate that metabolic end points at the molecular and organismal level are most sensitive to F-53B followed by PFOS and OBS. Collectively, F-53B has the highest bioconcentration potential and the strongest metabolism-disrupting effects, followed by PFOS and OBS. Our findings have important implications for the assessment of early developmental metabolic effects of PFOS alternatives F-53B and OBS in wildlife and humans. © 2019 American Chemical Society. This research work was supported by the National Natural Science Foundation of China (41867064 and 31860154), the Spanish Ministry of Education, Culture and Sport (FPU15/03332 and EST18/00001), the European Commission H2020-Marie Skłodowska-Curie Action MSCA-IF-RI-2017 (797725 EpiSTOX), and the Natural Sciences and Engineering Research Council of Canada (147476) and Canada Foundation of Innovation (148035). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|