Interactions of connexins with other membrane channels and transporters

Autor: Marc Chanson, Camillo Peracchia, Scott M. O'Grady, Basilio Aristides Kotsias
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Progress in Biophysics & Molecular Biology, Vol. 94, No 1-2 (2007) pp. 233-44
ISSN: 0079-6107
Popis: Cell-to-cell communication through gap junctions exists in most animal cells and is essential for many important biological processes including rapid transmission of electric signals to coordinate contraction of cardiac and smooth muscle, the intercellular propagation of Ca2+ waves and synchronization of physiological processes between adjacent cells within a tissue. Recent studies have shown that connexins (Cx) can have either direct or indirect interactions with other plasma membrane ion channels or membrane transport proteins with important functional consequences. For example, in tissues most severely affected by cystic fibrosis (CF), activation of the CF Transmembrane Conductance Regulator (CFTR) has been shown to influence connexin function. Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas interactions between aquaporin 4 (AQP4) and Cx43 in mouse astrocytes may coordinate the intercellular movement of ions and water between astrocytes. In this review, we discuss evidence supporting interactions between Cx and membrane channels/transporters including CFTR, aquaporins, ionotropic glutamate receptors, and between pannexin1, another class of putative gapjunction- forming proteins, and Kvb3, a regulatory b-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. within a tissue. Recent studies have shown that connexins (Cx) can have either direct or indirect interactions with other plasma membrane ion channels or membrane transport proteins with important functional consequences. For example, in tissues most severely affected by cystic fibrosis (CF), activation of the CF Transmembrane Conductance Regulator (CFTR) has been shown to influence connexin function. Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas interactions between aquaporin 4 (AQP4) and Cx43 in mouse astrocytes may coordinate the intercellular movement of ions and water between astrocytes. In this review, we discuss evidence supporting interactions between Cx and membrane channels/transporters including CFTR, aquaporins, ionotropic glutamate receptors, and between pannexin1, another class of putative gapjunction- forming proteins, and Kvb3, a regulatory b-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. within a tissue. Recent studies have shown that connexins (Cx) can have either direct or indirect interactions with other plasma membrane ion channels or membrane transport proteins with important functional consequences. For example, in tissues most severely affected by cystic fibrosis (CF), activation of the CF Transmembrane Conductance Regulator (CFTR) has been shown to influence connexin function. Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas interactions between aquaporin 4 (AQP4) and Cx43 in mouse astrocytes may coordinate the intercellular movement of ions and water between astrocytes. In this review, we discuss evidence supporting interactions between Cx and membrane channels/transporters including CFTR, aquaporins, ionotropic glutamate receptors, and between pannexin1, another class of putative gapjunction- forming proteins, and Kvb3, a regulatory b-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. within a tissue. Recent studies have shown that connexins (Cx) can have either direct or indirect interactions with other plasma membrane ion channels or membrane transport proteins with important functional consequences. For example, in tissues most severely affected by cystic fibrosis (CF), activation of the CF Transmembrane Conductance Regulator (CFTR) has been shown to influence connexin function. Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas interactions between aquaporin 4 (AQP4) and Cx43 in mouse astrocytes may coordinate the intercellular movement of ions and water between astrocytes. In this review, we discuss evidence supporting interactions between Cx and membrane channels/transporters including CFTR, aquaporins, ionotropic glutamate receptors, and between pannexin1, another class of putative gapjunction- forming proteins, and Kvb3, a regulatory b-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. 2+ waves and synchronization of physiological processes between adjacent cells within a tissue. Recent studies have shown that connexins (Cx) can have either direct or indirect interactions with other plasma membrane ion channels or membrane transport proteins with important functional consequences. For example, in tissues most severely affected by cystic fibrosis (CF), activation of the CF Transmembrane Conductance Regulator (CFTR) has been shown to influence connexin function. Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas interactions between aquaporin 4 (AQP4) and Cx43 in mouse astrocytes may coordinate the intercellular movement of ions and water between astrocytes. In this review, we discuss evidence supporting interactions between Cx and membrane channels/transporters including CFTR, aquaporins, ionotropic glutamate receptors, and between pannexin1, another class of putative gapjunction- forming proteins, and Kvb3, a regulatory b-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. b3, a regulatory b-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis. Fil: Chanson, Marc. Geneva University Hospitals; Suiza Fil: Kotsias, Basilio Aristides. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Peracchia, Camillo. University of Rochester; Estados Unidos Fil: O’Grady, Scott M.. University of Minnesota; Estados Unidos
Databáze: OpenAIRE
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