High MMP-1 mRNA Expression is a Risk Factor for Disease-Free and Overall Survivals in Patients with Invasive Breast Carcinoma
| Autor: | Toshimichi Asano, Jun-ichi Hamada, Shaoqiang Cheng, Taro Kuramae, Tetsuya Moriuchi, Yasuhiro Hida, Satoshi Hirano, Norihiro Takemoto, Mitsuhiro Tada, Masaki Miyamoto, Satoshi Kondo |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Mammary gland Estrogen receptor Breast Neoplasms Kaplan-Meier Estimate Matrix metalloproteinase Disease-Free Survival Metastasis Breast cancer Risk Factors Humans Medicine Neoplasm Invasiveness Breast RNA Messenger Aged Proportional Hazards Models Aged 80 and over business.industry Cancer Middle Aged Prognosis medicine.disease medicine.anatomical_structure Receptors Estrogen Multivariate Analysis Disease Progression Female Surgery Breast disease Matrix Metalloproteinase 1 business Breast carcinoma Follow-Up Studies |
| Zdroj: | Journal of Surgical Research. 146:104-109 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/j.jss.2007.05.032 |
| Popis: | Matrix metalloproteinase 1 (MMP-1) degrades extracellular matrix and thereby promotes tumor invasion and progression. In this study we examined the prognostic significance of tissue expression levels of MMP-1 mRNA in patients with invasive breast carcinoma.We assessed the prognostic value of MMP-1 mRNA expression in tumor tissue specimens from 85 breast carcinoma patients with a median follow-up time of 38 months (range, 2-48 months). MMP-1 mRNA levels were measured by real-time quantitative reverse transcriptase polymerase chain reaction (real time RT-PCR). The results were correlated with various clinicopathological parameters and clinical outcomes.mRNA expression levels of MMP-1 were higher in tumor tissue specimens than in adjacent normal breast tissue specimens from 15 patients (P0.023). MMP-1 mRNA levels showed no significant relationship with either tumor size or axillary node status but correlated inversely with estrogen receptor levels (P0.0043). High MMP-1 mRNA expression as determined by real-time RT-PCR correlated significantly with a high frequency of recurrence and fatal outcome (P0.025 and P0.020). Multivariate analysis using the Cox regression model indicated that high MMP-1 mRNA expression was an independent unfavorable prognostic factor (risk ratio, 6.37; P0.019).We have demonstrated for the first time the high mRNA expression of MMP-1 in patients whose carcinomas lack estrogen receptor expression. Our results suggest that MMP-1 is an important gene implicated in the progression of human breast cancer. |
| Databáze: | OpenAIRE |
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