Cyclin D1 G870A polymorphism and risk of colorectal cancer: a case control study
| Autor: | Fazl Q. Parray, Manzoor Ahmad Dar, Nissar A. Chowdri, Aga Syed Sameer, Mujeeb Zafar Banday, G. M. Gulzar, Saniya Nissar, Sabha Rasool, Mushtaq A. Siddiqi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Genotype Colorectal cancer Population Biology medicine.disease_cause Biochemistry Polymorphism Single Nucleotide Interviews as Topic Cyclin D1 Gene Frequency Risk Factors Internal medicine Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease education neoplasms Molecular Biology Aged education.field_of_study Oncogene Case-control study Middle Aged medicine.disease Molecular medicine digestive system diseases Case-Control Studies Molecular Medicine Female Carcinogenesis Colorectal Neoplasms |
| Zdroj: | Molecular medicine reports. 7(3) |
| ISSN: | 1791-3004 |
| Popis: | The present study aimed to analyse the role of cyclin D1 A870G polymorphism in modulating the susceptibility to colorectal cancer (CRC) in the Kashmiri population. The genotype distribution of the cyclin D1 gene in 130 CRC cases in comparison with 160 healthy controls was investigated. No direct significant association between cyclin D1 genotypes and CRC was observed; however, the AG and AA genotypes were found to be associated with an increased risk of CRC compared to the GG genotype, with an almost 2-fold increase in OR. This study suggests that the cyclin D1 polymorphism is associated with an increased risk of CRC in the Kashmiri population. |
| Databáze: | OpenAIRE |
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