Decrease in Adhesion Formation by a Single Application of 5-Fluorouracil after Flexor Tendon Injury
| Autor: | Augustine Akali, Peng T. Khaw, Umraz Khan, Angus D. Mcgrouther |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Contraction (grammar) Antimetabolites medicine.medical_treatment Tissue Adhesions Hindlimb Synovial sheath Tendons Postoperative Complications Tendon Injuries medicine Animals Trabeculectomy Lagomorpha biology Foot business.industry Mitomycin C musculoskeletal system biology.organism_classification Surgery Tendon medicine.anatomical_structure Fluorouracil Rabbits business Complication |
| Zdroj: | Plastic and Reconstructive Surgery. 103:151-158 |
| ISSN: | 0032-1052 |
| DOI: | 10.1097/00006534-199901000-00024 |
| Popis: | Using an animal model, the effect of a single intraoperative application of 5-fluorouracil on digital flexor tendon adhesions was assessed. After a standard partial division of the tendon and immobilization with a stitch, the synovial sheath in 30 rabbit tendons was treated with 5-fluorouracil solution (50 mg/ml)-soaked sponge pledgets for 5 minutes. Buffered saline was substituted for 5-fluorouracil in 30 control tendons. The tendons were harvested 1 week postoperatively, and histologic sections were assessed with a light microscope. There was a significant reduction in synovial sheath thickening (p < 0.001), cell counts (p < 0.001) and proportional length of adhesions (p < 0.001) in the treated tendons. The reduction in synovial reaction and adhesion formation using this "one touch" technique presents a novel strategy for the management of the clinical problem of postoperative adhesions complicating tendon injury and repair. |
| Databáze: | OpenAIRE |
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