Biomedical and Pharmaceutical Applications
| Autor: | Volker Nischwitz, Gunda Koellensperger, Tamara García-Barrera, Julia Bornhorst, Jordan Sonet, José Luis Gómez-Ariza, Bernhard Michalke, Luis Galvez, Carlo Barbante, Laurent Chavatte, Anne-Laure Bulteau, Katharina Neth, Belén Callejón-Leblic, Bernhard K. Keppler, Sarah Theiner, Marco Roman |
|---|---|
| Přispěvatelé: | Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Chemistry
Cerebrospinal fluid samples 010401 analytical chemistry 02 engineering and technology Alzheimer's disease Selenium biology 021001 nanoscience & nanotechnology 01 natural sciences 3. Good health 0104 chemical sciences Biomedical samples Selenium speciation analysis Manganese speciation analysis [CHIM.ANAL]Chemical Sciences/Analytical chemistry Mass spectrometry imaging techniques [CHIM]Chemical Sciences 0210 nano-technology Selenoproteins |
| Zdroj: | Metallomics Analytical Techniques and Speciation Methods Metallomics Analytical Techniques and Speciation Methods, Wiley-VCH Verlag, pp.359-462, 2016, 9783527694907 ⟨10.1002/9783527694907.ch13⟩ Metallomics ISBN: 9783527339693 Metallomics |
| DOI: | 10.1002/9783527694907.ch13 |
| Popis: | International audience; This chapter reviews the current knowledge of important functions of selenium (Se) and selenoproteins in physiology and pathology in human. The outcome of the different clinical trials reveals the need for a better understanding of Se biology. The physiology of Se depends on its continuous supply to the body and its optimal distribution to tissues. The development and application of mass spectrometry imaging (MSI) techniques are of great interest in cancer research and diagnosis to study elemental distributions in biological tissue samples at microscopic level. The ability to record spatial accumulation of multiple analytes in tissue samples under native conditions and to directly correlate obtained images with histological features has made MSI an invaluable analytical tool. The chapter concentrates on literature about manganese (Mn) speciation targeting neurodegeneration effects, first, in human samples, such as serum or cerebrospinal fluid (CSF) samples, where some studies were summarized in 2007. It also presents a case study of Alzheimer's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|