Review article
| Autor: | Min Chen, Peter Heeringa, Mirjan M. van Timmeren |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Inflammation
urologic and male genital diseases ALTERNATIVE PATHWAY ISCHEMIA-REPERFUSION WEGENERS-GRANULOMATOSIS immune system diseases medicine Rapidly progressive glomerulonephritis ANTIMYELOPEROXIDASE ANTIBODIES cardiovascular diseases skin and connective tissue diseases rapidly progressive glomerulonephritis biology HUMAN POLYMORPHONUCLEAR LEUKOCYTES business.industry COLLAGEN-INDUCED ARTHRITIS C5A RECEPTOR ANTAGONIST Experimental autoimmune encephalomyelitis neutrophil General Medicine alternative complement pathway anti-MPO medicine.disease Review article Complement system respiratory tract diseases anti-Pr3 Nephrology EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Immunology Alternative complement pathway biology.protein medicine.symptom Antibody Vasculitis business CRESCENTIC GLOMERULONEPHRITIS INTERACTIONS IN-VIVO |
| Zdroj: | Nephrology. 14(1):16-25 |
| ISSN: | 1320-5358 |
| Popis: | Small-vessel vasculitides associated with anti-neutrophil cytoplasmic auto-antibodies (ANCA) are severe systemic diseases that may affect any organ. Increasing evidence from clinical, animal and in vitro studies indicates that ANCA are causally involved in disease pathogenesis mainly through activation of neutrophils resulting in endothelial cell injury. Recent studies suggest a previously unsuspected but crucial role for alternative pathway complement activation in ANCA disease pathogenesis. In this brief review, we will discuss the evidence for complement system activation in ANCA-associated vasculitides and propose a working model that links ANCA, neutrophils and complement activation in causing an inflammatory amplification loop that may explain the severe leukocytoclastic inflammation that is typical for ANCA-associated vasculitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|