The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic β-cells

Autor:	Shalinee Dhayal, Eleftheria Diakogiannaki, Hannah J. Welters, Noel G. Morgan
Rok vydání:	2008
Předmět:	Cell Survival Cell Type 2 diabetes Biology medicine.disease Biochemistry Cytoprotection In vitro medicine.anatomical_structure Apoptosis Insulin-Secreting Cells Fatty Acids Unsaturated medicine biology.protein Animals Humans adipocyte protein 2 Long chain Function (biology)
Zdroj:	Biochemical Society Transactions. 36:905-908
ISSN:	1470-8752 0300-5127
DOI:	10.1042/bst0360905
Popis:	Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence of Type 2 diabetes in humans. However, when incubated in vitro, β-cells respond differentially to long-chain saturated and mono-unsaturated fatty acids, suggesting that these molecules may regulate cell functionality by different mechanisms. In particular, it is clear that, whereas saturated fatty acids [e.g. palmitate (C16:0)] exert detrimental effects on β-cells, the equivalent mono-unsaturated species [e.g. palmitoleate (C16:1)] are well tolerated. Indeed, mono-unsaturated species are potently cytoprotective. The present review explores the differential effects of these various fatty acids on β-cell viability and considers the possible mechanisms involved in cytoprotection by mono-unsaturates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1af72e8dc3b5346bcc49e5d1a68329 https://doi.org/10.1042/bst0360905 Zobrazit plný text záznamu