Association between Anaesthetic Technique and Oncological Outcomes after Colorectal Carcinoma Liver Metastasis Resection
| Autor: | Hao Gao, Jin-Chao Song, Hong-Qian Wang, Ai-Ling Guo, Xiao-Yan Meng, Feng-Feng Zhu, Weifeng Yu, Mei Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Anesthesia
Epidural Male medicine.medical_specialty China Multivariate analysis Colorectal cancer Anesthesia General Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans General anaesthesia Univariate analysis business.industry Hazard ratio Carcinoma Liver Neoplasms General Medicine Perioperative Middle Aged medicine.disease Quartile Liver 030211 gastroenterology & hepatology Female business Colorectal Neoplasms Cohort study Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Background: Recently published studies suggest that the anaesthetic technique used during oncologic surgery can improve patient outcomes. Therefore, the authors evaluated the survival of patients with resected colorectal carcinoma liver metastases (CRCLMs) who received either EGA (general anaesthesia [GA] combined with epidural anaesthesia [EA]) or GA alone. Methods: We conducted an ambispective cohort study including 225 post-surgical CRCLM patients between May 2007 and July 2012 and performed a follow-up investigation of survival in July 2017. Results: The basic characteristics in the two groups were largely similar. The median (quartiles) recurrence interval for all patients was 10 (2.5, 23) months, and the median (quartiles) survival for CRCLM patients post-surgically was 37 (30.5, 51.5) months. Perioperative EA was associated with survival (P =0.039, log-rank test), with an estimated hazard ratio of 0.737 (95% CI 0.551-0.985) in the univariate analysis. Kaplan-Meier estimates of survival for GA and EGA suggested that GA might provide better outcomes than EGA [P=0.028, hazard ratio of 0.7328 (95% CI 0.5433-0.9884)]. Significant differences in anaesthesia techniques were found (P=0.048), with an adjusted estimated hazard ratio of 0.741 (95% CI 0.550-0.998) in the multivariate analysis. Subgroup analyses of patients in different age groups (< 40, ≥ 40 but |
| Databáze: | OpenAIRE |
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