The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis
| Autor: | Walker N. Oliveira, Andreza S. Dórea, Pedro P. Carneiro, Maurício T. Nascimento, Lucas P. Carvalho, Paulo R. L. Machado, Albert Schriefer, Olívia Bacellar, Edgar M. Carvalho |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Immunology Leishmaniasis inflammatory response Biology medicine.disease Leishmania biology.organism_classification Microbiology Parasite load Peripheral blood mononuclear cell QR1-502 Respiratory burst Pathogenesis cutaneous leishmaniasis Infectious Diseases Cutaneous leishmaniasis medicine Parasite hosting monocytes Leishmania (Viannia) braziliensis disseminated leishmaniasis |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
| ISSN: | 2235-2988 |
| Popis: | Disseminated Leishmaniasis (DL) is an emerging and severe form ofLeishmania (Viannia) braziliensisinfection defined by the presence of 10 and up to more than 1,000 skin lesions. The mechanisms underlying parasite dissemination remain unknown. Genotypic differences among species ofL. braziliensishave been associated with different clinical forms of disease. The present work compared the function of monocytes obtained from patients with cutaneous leishmaniasis (CL) and DL in response to infection withL. braziliensisisolates of both these two clinical forms of disease. Mononuclear cells obtained from DL and CL patients were infected with differentL. braziliensisisolates, and numbers of infected cells, parasite load, respiratory burst, TLR2 and TLR4 expression and cytokine production were evaluated. DL isolates infected more monocytes, induced greater respiratory burst, and more cytokine production compared to isolates from CL patients regardless of the origin of monocytes (DL or CL). However, greater parasite multiplication and higher TLR2 and TLR4 expression were seen in monocytes from DL patients compared to CL following infection with DL isolates. Our results indicate the participation of both parasite genotype and host factors in the pathogenesis of DL. |
| Databáze: | OpenAIRE |
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