The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise
| Autor: | Alexandre Garcia, Luiza Freitas Lopes, Pâmela Billig Mello-Carpes, Ben-Hur Souto das Neves, Daniel Ventura Dias, Caroline Bitencourt Soares, Letícia Rossi Daré |
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| Rok vydání: | 2020 |
| Předmět: |
Cognitive Neuroscience
Physical exercise oxidative damage Brain damage Hippocampal formation lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine physical exercise Neuroplasticity Medicine Dementia lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry cognitive exercise Original Research 030304 developmental biology Recognition memory 0303 health sciences Aβ neurotoxicity business.industry Neurotoxicity Cognition medicine.disease Neuropsychology and Physiological Psychology medicine.symptom business Alzheimer’s disease Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Behavioral Neuroscience Frontiers in Behavioral Neuroscience, Vol 14 (2020) |
| ISSN: | 1662-5153 |
| DOI: | 10.3389/fnbeh.2020.00152 |
| Popis: | Alzheimer’s disease (AD) is the leading cause of dementia in the world, accounting for 50–75% of cases. Currently, there is limited treatment for AD. The current pharmacological therapy minimizes symptom progression but does not reverse brain damage. Studies focused on nonpharmacological treatment for AD have been developed to act on brain plasticity and minimize the neurotoxicity caused by the amyloid-beta (Aβ) peptide. Using a neurotoxicity model induced by Aβ in rats, the present study shows that physical (PE) and cognitive exercise (CE) reverse recognition memory deficits (with a prominent effect of long-term object recognition memory), decrease hippocampal lipid peroxidation, restore the acetylcholinesterase activity altered by Aβ neurotoxicity, and seems to reverse, at least partially, hippocampal tissue disorganization. |
| Databáze: | OpenAIRE |
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