Treatment of recurrent complicated urinary tract infections in children with vesicoureteral reflux
| Autor: | Chung-Ming Huang, Ya-Li Chien, Chia-Man Chou, Chin-Fu Lin, Fang-Liang Huang, Tsung-Hua Wu, Po-Yen Chen, Lin-Shien Fu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Cefotaxime 030232 urology & nephrology Cefazolin Ceftazidime Pilot Projects Drug resistance urologic and male genital diseases drug susceptibility 0302 clinical medicine Recurrence Drug Resistance Multiple Bacterial Immunology and Allergy 030212 general & internal medicine Child Escherichia coli Infections Incidence (epidemiology) General Medicine female genital diseases and pregnancy complications Anti-Bacterial Agents Infectious Diseases Amikacin Child Preschool Urinary Tract Infections Drug Therapy Combination Female medicine.drug Microbiology (medical) medicine.medical_specialty Adolescent Urology Taiwan Fosfomycin Vesicoureteral reflux 03 medical and health sciences children Internal medicine Immunology and Microbiology(all) medicine Escherichia coli Humans Retrospective Studies Vesico-Ureteral Reflux General Immunology and Microbiology business.industry Infant vesicoureteral reflux medicine.disease bacterial infections and mycoses business urinary tract infection |
| Zdroj: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 49(5) |
| ISSN: | 1995-9133 |
| Popis: | BackgroundUrinary tract infections (UTIs) in children with vesicoureteral reflux (VUR) are often caused by uropathogens with a high rate of drug resistance and are associated with a high rate of recurrence with a single pathogen. In this study, we evaluated the incidence of recurrent UTI and the drug resistance pattern of Escherichia coli in children with VUR. We also evaluated whether combination therapy comprising fosomycin plus one other antimicrobial agent is effective for treatment of recurrent UTIs.MethodsWe retrospectively reviewed the medical records of all children with VUR who developed at least one episode of UTI during the period January 1, 2003 to December 31, 2013 at a single medical center. The effectiveness of fosfomycin plus amikicin for Enterobacteriaceae or ceftazidime for Pseudomonas aeruginosa infections was prospectively studied in six children with recurrent relapsing UTIs.ResultsThe study population comprised 129 children (age range, from 1month to 15 years; mean ± standard deviation, 2.37 ± 2.91 years) with VUR who developed at least one UTI during the 10-year study period; 68 (52.7%) had recurrent UTIs. The presence of an underlying urinary tract anomaly was predictive of recurrence (p = 0.028). The rates of susceptibility of E. coli to cefazolin (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|