Aquaporin-1 in blood vessels of rat circumventricular organs
| Autor: | Alan J. Wilson, Colin Carati, Tim Chataway, Bren Gannon, Rainer Viktor Haberberger |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Histology Blood–brain barrier Pineal Gland Pathology and Forensic Medicine Rats Sprague-Dawley Animals Medicine RNA Messenger Microvessel Circumventricular organs Brain Mapping Aquaporin 1 Reverse Transcriptase Polymerase Chain Reaction business.industry Area postrema Median Eminence Cell Biology Anatomy Immunohistochemistry Neurosecretory Systems Subfornical organ Rats medicine.anatomical_structure Area Postrema Blood-Brain Barrier Median eminence Choroid Plexus cardiovascular system Blood Vessels Female Choroid plexus Endothelium Vascular business Subcommissural organ Subfornical Organ |
| Zdroj: | Cell and Tissue Research. 340:159-168 |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-010-0927-2 |
| Popis: | Although the water channel protein aquaporin-1 (AQP1) is widely observed outside the rat brain in continuous, but not fenestrated, vascular endothelia, it has not previously been observed in any endothelia within the normal rat brain and only to a limited extent in the human brain. In this immunohistochemical study of rat brain, AQP1 has also been found in microvessel endothelia, probably of the fenestrated type, in all circumventricular organs (except the subcommissural organ and the vascular organ of the lamina terminalis): in the median eminence, pineal, subfornical organ, area postrema and choroid plexus. The majority of microvessels in the median eminence, pineal and choroid plexus, known to be exclusively fenestrated, are shown to be AQP1-immunoreactive. In the subfornical organ and area postrema in which many, but not all, microvessels are fenestrated, not all microvessels are AQP1-immunoreactive. In the AQP1-immunoreactive microvessels, the AQP1 probably facilitates water movement between blood and interstitium as one component of the normal fluxes that occur in these specialised sensory and secretory areas. AQP1-immunoreactive endothelia have also been seen in a small population of blood vessels in the cerebral parenchyma outside the circumventricular organs, similar to other observations in human brain. The proposed development of AQP1 modulators to treat various brain pathologies in which AQP1 plays a deleterious role will necessitate further work to determine the effect of such modulators on the normal function of the circumventricular organs. |
| Databáze: | OpenAIRE |
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