Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential
| Autor: | Regina Célia de Oliveira, Christopher William Fagg, José Beethoven Figueiredo Barbosa, Julia Sonsin-Oliveira, Eloisa Dutra Caldas, Beatriz Werneck Lopes Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Tetrahydroharmine
Dimethyltryptamine Plant Science Malpighiaceae Article 03 medical and health sciences Harmaline chemistry.chemical_compound 0302 clinical medicine Harmine Banisteriopsis caapi Acre Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Ecology biology Traditional medicine Chemistry DMT Botany Ayahuasca biology.organism_classification Betacarbolina QK1-989 ß-carbolines Cipó-mariri 030217 neurology & neurosurgery Brazil ayahuasca |
| Zdroj: | Plants Volume 9 Issue 7 Plants, Vol 9, Iss 870, p 870 (2020) Multidisciplinary Digital Publishing Institute UnpayWall ORCID Microsoft Academic Graph PubMed Central DOAJ-Articles LAReferencia-Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas Universidade de Brasília (UnB) instacron:UNB Repositório Institucional da UnB |
| ISSN: | 2223-7747 |
| DOI: | 10.3390/plants9070870 |
| Popis: | carbolines, except for one D. pubipetala sample. Concentrations in ayahuasca samples ranged from 0.109 to 7.11 mg/mL harmine, 0.012 to 0.945 mg/mL harmaline, 0.09 to 3.05 mg/mL THH, and 0.10 to 3.12 mg/mL DMT. The analysis of paired ayahuasca/B. caapi confirmed that harmine is reduced to harmaline and to THH during the brew preparation. This is the largest study conducted with Malpighiaceae samples and showed a large variability in the main &beta carbolines, and Psichotria virids, which contains the serotonin receptor agonist N,N dimethyltryptamine (DMT). The objectives of this study were to investigate the chemical profile of B. caapi and of ayahuasca collected in various Brazilian regions. In total, 176 plant lianas, of which 159 B. caapi and 33 ayahuasca samples were analyzed. Dried liana samples were powdered, extracted with methanol, diluted, and analyzed by LC-MS/MS. Ayahuasca samples were diluted and analyzed. Mean concentrations in B. caapi were 4.79 mg/g harmine, 0.451 mg/g harmaline, and 2.18 mg/g tetrahydroharmine (THH), with a high variability among the samples (RSD from 78.9 to 170%). Native B. caapi samples showed significantly higher harmine concentrations than cultivated ones, and samples from the Federal District/Goiá s had higher THH content than those collected in the State of Acre. The other Malpighiaceae samples did not contain &beta Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors &beta carbolines present in B. caapi. This biodiversity is a challenge for standardization of the material used in ethnopharmacological studies of B. caapi and ayahuasca. |
| Databáze: | OpenAIRE |
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