Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss
| Autor: | Heikki V. Sarin, Ivan Gudelj, Jarno Honkanen, Johanna K. Ihalainen, Arja Vuorela, Joseph H. Lee, Zhenzhen Jin, Joseph D. Terwilliger, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Julija Jurić, Gordan Lauc, Kati Kristiansson, Juha J. Hulmi, Markus Perola |
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| Přispěvatelé: | Research Programs Unit, Faculty of Medicine, CAMM - Research Program for Clinical and Molecular Metabolism, University of Helsinki, Clinicum, Quantitative Genetics, Department of Physiology, Medicum, HUS Children and Adolescents |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Physiology liikunta Overweight Systemic inflammation Leukocyte Count physical training 0302 clinical medicine Weight loss Leukocytes Immunology and Allergy Medicine OXIDATIVE STRESS ta315 DIETARY RESTRICTION Sport and Fitness Sciences Original Research 2. Zero hunger immunosuppression Idrottsvetenskap bioinformatiikka Immunosuppression bioinformatics low energy availability 3. Good health immuunivaste IMMUNE FUNCTION OBESITY Chemokine secretion Female medicine.symptom fyysinen aktiivisuus Adult lcsh:Immunologic diseases. Allergy Immunology EXERCISE Inflammation Young Adult 03 medical and health sciences LEPTIN Immune system INFLAMMATION Immune Tolerance Humans weight loss Cell Proliferation business.industry laihdutus CYTOKINES medicine.disease Obesity Diet energiansaanti 030104 developmental biology HEMATOPOIETIC STEM Immunoglobulin G 3121 General medicine internal medicine and other clinical medicine CELLS 3111 Biomedicine Energy Intake Transcriptome lcsh:RC581-607 business 030215 immunology |
| Zdroj: | Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2019.00907 |
| Popis: | Exercise and exercise-induced weight loss have a beneficial effect on overall health, including positive effects on molecular pathways associated with immune function, especially in overweight individuals. The main aim of our study was to assess how energy deprivation (i.e., "semi-starvation") leading to substantial fat mass loss affects the immune system and immunosuppression in previously normal weight individuals. Thus, to address this hypothesis, we applied a high-throughput systems biology approach to better characterize potential key pathways associated with immune system modulation during intensive weight loss and subsequent weight regain. We examined 42 healthy female physique athletes (age 27.5 +/- 4.0 years, body mass index 23.4 +/- 1.7 kg/m(2)) volunteered into either a diet group (n = 25) or a control group (n = 17). For the diet group, the energy intake was reduced and exercise levels were increased to induce loss of fat mass that was subsequently regained during a recovery period. The control group was instructed to maintain their typical lifestyle, exercise levels, and energy intake at a constant level. For quantification of systems biology markers, fasting blood samples were drawn at three time points: baseline (PRE), at the end of the weight loss period (MID 21.1 +/- 3.1 weeks after PRE), and at the end of the weight regain period (POST 18.4 +/- 2.9 weeks after MID). In contrast to the control group, the diet group showed significant (false discovery rate |
| Databáze: | OpenAIRE |
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