IOIBD technical review on endoscopic indices for Crohn's disease clinical trials
| Autor: | Severine Vermeire, Mark Löwenberg, P Marteau, Brian G. Feagan, Simon Travis, Barrett G. Levesque, Silvio Danese, Gionata Fiorino, W J Sandborn, L Vuitton, G. D'Haens, Jean-Yves Mary, Laurent Peyrin-Biroulet, Reena Khanna |
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| Přispěvatelé: | Vuitton, L, Marteau, P, Sandborn, Wj, Levesque, Bg, Feagan, B, Vermeire, S, Danese, S, D'Haens, G, Lowenberg, M, Khanna, R, Fiorino, G, Travis, S, Mary, Jy, Peyrin-Biroulet, L, Service de gastro-entérologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Gastroentérologie [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Division of Gastroenterology, University of California [San Diego] (UC San Diego), University of California-University of California, Robarts Clinical Trials, Robarts Research Institute [Canada], University of Western Ontario (UWO)-University of Western Ontario (UWO), Department of Gastroenterology [Leuven=Louvain], University Hospitals Leuven [Leuven], Humanitas Research Hospital, Department of Gastroenterology and Hepatology [Academic Medical Center Amsterdam], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), John Radcliffe Hospital [Oxford University Hospital], Biostatistique et épidemiologie clinique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2016 |
| Předmět: |
Research design
medicine.medical_specialty [SDV]Life Sciences [q-bio] Crohn's Disease Disease Inflammatory bowel disease Severity of Illness Index Endoscopy Gastrointestinal 03 medical and health sciences 0302 clinical medicine Intestinal mucosa Crohn Disease Internal medicine Severity of illness medicine Humans Intestinal Mucosa Monitoring Physiologic Crohn's disease Clinical Trials as Topic business.industry Gold standard Remission Induction Gastroenterology Patient Acuity medicine.disease 3. Good health Surgery Clinical trial Research Design 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business |
| Zdroj: | Gut Gut, BMJ Publishing Group, 2016, 65 (9), pp.1447-1455. ⟨10.1136/gutjnl-2015-309903⟩ |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gutjnl-2015-309903⟩ |
| Popis: | International audience; BACKGROUND:Crohn's disease (CD) is a chronic disabling and progressive IBD. Only strategies looking beyond symptoms and based on tight monitoring of objective signs of inflammation such as mucosal lesions may have the potential for disease modification. Endoscopic evaluation is currently the gold standard to assess mucosal lesions and has become a major therapeutic endpoint in clinical trials. Several endoscopic indices have been proposed to evaluate disease activity; unvalidated and arbitrary definitions have been used in clinical trials for defining endoscopic response and endoscopic remission in CD.METHODS:In these recommendations from the International Organization for the Study of Inflammatory Bowel Disease, we first reviewed all technical aspects of available endoscopic scoring systems in the literature. Second, in order to achieve consensus on endoscopic definitions of remission and response in trials, a two-round vote based on a Delphi method was performed among 14 specialists in the field of IBDs.RESULTS:At the end of the voting process, the investigators ranked first a >50% decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) or Crohn's Disease Endoscopic Index of Severity for the definition of endoscopic response, and an SES-CD 0-2 for the definition of endoscopic remission in CD. All experts agreed on a Rutgeerts' score i0-i1 for the definition of endoscopic remission after surgery. |
| Databáze: | OpenAIRE |
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